CAS 100007-54-3

3',4'-dihydroxyetoposide

Description:

3',4'-Dihydroxyetoposide, with the CAS number 100007-54-3, is a derivative of etoposide, which is a well-known chemotherapeutic agent used primarily in the treatment of various cancers, including testicular cancer and lung cancer. This compound features two hydroxyl (-OH) groups at the 3' and 4' positions of its phenolic ring, which enhances its solubility and may influence its pharmacological properties. The presence of these hydroxyl groups can also affect the compound's interaction with DNA and topoisomerase II, the target enzyme for etoposide, potentially altering its efficacy and toxicity profile. 3',4'-Dihydroxyetoposide is characterized by its ability to form hydrogen bonds, which may enhance its binding affinity to biological targets. Additionally, it may exhibit antioxidant properties due to the presence of the hydroxyl groups. As a chemical entity, it is important in research settings for understanding the structure-activity relationship of etoposide derivatives and their potential therapeutic applications.

Formula: C₃₅H₃₈O₁₅

InChI: InChI=1/C29H32O13.C6H6O2/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3;7-5-3-1-2-4-6(5)8/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3;1-4,7-8H/t11-,15?,20-,21-,22+,24-,25-,26?,27-,29+;/m1./s1

Synonyms:

• 3',4'-Dihydroxy-VP 16-213
• Dhvp-16-213
• Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5-(3,4-dihydroxy-5-methoxyphenyl)-9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
• (5S,5aR,8aR,9R)-9-(3,4-dihydroxy-5-methoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside

3’-O-Desmethyl Etoposide

Controlled Product

CAS: 100007-54-3

Applications An Etoposide (E933750) metabolite
References Relling, M., et al.: Mol. Pharmacol., 45, 352 (1994), Lovett, B., et al.: Biochem., 40, 1159 (2001), Zhuo, X., et al.: Drug Metab. Disposition, 32, 993 (2004), Fan, Y., et al.: Chem. Res. Toxicol., 19, 937 (2006),

Formula: C₂₈H₃₀O₁₃

Color and Shape: Neat

Molecular weight: 574.53

Ref: TR-D291970

3’-O-Desmethyl Etoposide-d4 (~ 90%)

Controlled Product

CAS: 100007-54-3

Applications 3’-O-Desmethyl Etoposide-d4, is the labeled analogue of 3’-O-Desmethyl Etoposide (D291970); which is an Etoposide (E933750) metabolite.
References Relling, M., et al.: Mol. Pharmacol., 45, 352 (1994), Lovett, B., et al.: Biochem., 40, 1159 (2001), Zhuo, X., et al.: Drug Metab. Disposition, 32, 993 (2004), Fan, Y., et al.: Chem. Res. Toxicol., 19, 937 (2006),

Formula: C₂₈D₄H₂₆O₁₃

Purity: ~90%

Color and Shape: Light Brown

Molecular weight: 578.555

Ref: TR-D291972

3’-O-Desmethyl Etoposide

CAS: 100007-54-3

Formula: C₂₈H₃₀O₁₃

Molecular weight: 574.54

Ref: ST-EA-CP-E31032