CAS 100114-42-9

α-Amino-3-methyl-5-isoxazoleacetic acid

Description:

α-Amino-3-methyl-5-isoxazoleacetic acid, commonly known as AMPA, is a chemical compound that serves as a potent agonist for the AMPA subtype of glutamate receptors in the central nervous system. It is characterized by its isoxazole ring structure, which contributes to its biological activity. AMPA is a white to off-white crystalline powder that is soluble in water and exhibits a relatively stable nature under standard conditions. The compound plays a significant role in neurotransmission and is involved in various physiological processes, including synaptic plasticity and learning. Its chemical formula includes an amino group, which is essential for its interaction with glutamate receptors. AMPA is often utilized in pharmacological research to study excitatory neurotransmission and has implications in understanding neurological disorders. Due to its specific receptor activity, it is also of interest in the development of drugs targeting cognitive functions and neuroprotection. Safety and handling precautions are necessary, as with many chemical substances, to mitigate any potential risks associated with its use.

Formula: C₆H₈N₂O₃

InChI: InChI=1S/C6H8N2O3/c1-3-2-4(11-8-3)5(7)6(9)10/h2,5H,7H2,1H3,(H,9,10)

InChI key: InChIKey=XJMLTMHANGOCQE-UHFFFAOYSA-N

SMILES: C(C(O)=O)(N)C=1ON=C(C)C1

Synonyms:

• 2-Amino-2-(3-methylisoxazol-5-yl)acetic acid
• 5-Isoxazoleacetic acid, α-amino-3-methyl-
• α-Amino-3-methyl-5-isoxazoleacetic acid
• 2-Amino-2-(3-methyl-1,2-oxazol-5-yl)acetic acid