CAS 1002347-71-8

SIMVASTATIN-D6

Description:

Simvastatin-D6 is a deuterated form of simvastatin, a medication primarily used to lower cholesterol levels and reduce the risk of cardiovascular disease. The "D6" designation indicates that six hydrogen atoms in the simvastatin molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the compound's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in metabolic studies and drug metabolism investigations. Simvastatin itself is a member of the statin class of drugs, which work by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol biosynthesis. The deuterated version may also be utilized in tracer studies to better understand the drug's behavior in biological systems. In terms of physical properties, simvastatin-D6 is expected to exhibit similar characteristics to its non-deuterated counterpart, including solubility in organic solvents and a specific melting point, although the exact values may differ due to the isotopic substitution. As with all pharmaceuticals, handling and usage should adhere to safety guidelines and regulations.

Formula: C₂₅H₃₂D₆O₅

Synonyms:

• SIMVASTATIN-D6
• 6
• Simvastatin-d

Simvastatin-d6

CAS: 1002347-71-8

Formula: C₂₅H₃₂D₆O₅

Color and Shape: White To Off-White Solid

Molecular weight: 424.61

Ref: 4Z-S-122

Simvastatin Impurity 1

CAS: 1002347-71-8

Formula: C₃₀H₅₁NO₅

Color and Shape: White To Off-White Solid

Molecular weight: 505.74

Ref: 4Z-S-1228

Simvastatin-d6

Controlled Product

CAS: 1002347-71-8

Stability Hygroscopic
Applications Deuterated Simvastatin, a competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),

Formula: C₂₅H₃₂D₆O₅

Color and Shape: White To Off-White

Molecular weight: 424.6

Ref: TR-S485002

Simvastatin-d6

CAS: 1002347-71-8

Simvastatin is a drug that inhibits the synthesis of cholesterol, and is used to treat high cholesterol levels. It is a lipophilic drug that binds to the enzyme hydroxyl-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase), which regulates the production of cholesterol in the liver. Simvastatin has a long half-life and is metabolized by hepatic esterases and glucuronidases, which allow it to be eliminated through bile. The pharmacokinetics of simvastatin are affected by its uptake into human serum lipoproteins. Simvastatin may also act as a transporter for other drugs.

Formula: C₂₅H₃₈O₅

Purity: Min. 95%

Molecular weight: 418.6 g/mol

Ref: 3D-CQB34771