CAS 100239-44-9

3α-Hydroxytibolone

Description:

3α-Hydroxytibolone, with the CAS number 100239-44-9, is a synthetic steroid and a derivative of tibolone, which is primarily used in hormone replacement therapy. This compound exhibits a unique structure that includes a hydroxyl group at the 3α position, contributing to its biological activity. It is characterized by its ability to selectively bind to estrogen receptors, thereby mimicking estrogenic effects in certain tissues while exhibiting anti-estrogenic properties in others. This selective action makes it beneficial for alleviating menopausal symptoms, such as hot flashes and osteoporosis, while minimizing the risk of estrogen-related side effects. Additionally, 3α-Hydroxytibolone has been studied for its potential effects on lipid metabolism and bone density. Its pharmacokinetics involve metabolism primarily in the liver, leading to active metabolites that exert therapeutic effects. Overall, 3α-Hydroxytibolone represents a significant advancement in the development of selective estrogen receptor modulators (SERMs) for clinical use.

Formula: C₂₁H₃₀O₂

InChI: InChI=1S/C21H30O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,15,17-19,22-23H,5-12H2,2-3H3/t13-,15-,17-,18+,19-,20+,21+/m1/s1

InChI key: InChIKey=YLEUWNOTNJZCBN-CZTKNSHGSA-N

SMILES: C[C@H]1[C@]2([C@]3([C@@](C)([C@@](C#C)(O)CC3)CC[C@@]2(C4=C(C1)C[C@H](O)CC4)[H])[H])[H]

Synonyms:

• (3A,7A,17A)-3,17-Dihydroxy-7-Methyl-19-Norpregn-5(10)-En-20-Yl-3-One
• (3α,7α,17α)-7-Methyl-19-norpregn-5(10)-en-20-yne-3,17-diol
• 19-Norpregn-5(10)-en-20-yne-3,17-diol, 7-methyl-, (3α,7α,17α)-
• 3-alpha-Hydroxytibolone
• Org 4094
• 3α-Hydroxytibolone

3α-Hydroxy Tibolone

Controlled Product

CAS: 100239-44-9

Applications A metabolite of Tibolone. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
References Belman, S., et al.: Cancer Res., 32, 450 (1972), Shirahashi, H., et al.: Chem. Pharm. Bull., 41, 1664 (1993), Hoyte, R., et al.: Steroids, 58, 13 (1993), Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Colombo, D., et al.: Eur. J. Med. Chem., 40, 69 (2005),

Formula: C₂₁H₃₀O₂

Color and Shape: White To Off-White

Molecular weight: 314.46

Ref: TR-H964250

3-Hydroxy Tibolone-d5 (mixture of 3α & 3β isomers)

Controlled Product

CAS: 100239-44-9

Applications 3-Hydroxy Tibolone-d5, is the labeled analogue of 3-Hydroxy Tibolone, a synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Belman, S., et al.: Cancer Res., 32, 450 (1972), Shirahashi, H., et al.: Chem. Pharm. Bull., 41, 1664 (1993), Hoyte, R., et al.: Steroids, 58, 13 (1993), Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Colombo, D., et al.: Eur. J. Med. Chem., 40, 69 (2005),

Formula: C₂₁H₂₅D₅O₂

Color and Shape: Neat

Molecular weight: 319.49

Ref: TR-H964253

3α-Hydroxy Tibolone (1mg/ml in Acetonitrile)

Controlled Product

CAS: 100239-44-9

Formula: C₂₁H₃₀O₂

Color and Shape: Single Solution

Molecular weight: 314.46

Ref: TR-KIT5350

3α-Hydroxy Tibolone-13C,d3 (1mg/ml in Acetonitrile)

Controlled Product

CAS: 100239-44-9

Formula: C₂₀₁₃CH₂₇D₃O₂

Color and Shape: Single Solution

Molecular weight: 318.47

Ref: TR-KIT5355

3a-Hydroxy Tibolone-13C,d3

Controlled Product

CAS: 100239-44-9

Formula: C₂₀₁₃CH₂₇D₃O₂

Color and Shape: Neat

Molecular weight: 318.47

Ref: TR-H964252

3a-Hydroxy tibolone

Controlled Product

CAS: 100239-44-9

Tibolone is a synthetic hormone that is used in the treatment of menopausal symptoms and breast cancer. Tibolone has been shown to be an effective treatment for menopausal symptoms, such as hot flashes and vaginal dryness, by providing relief from these symptoms. Tibolone has also been shown to have anti-cancer effects. This drug may be useful for treating breast cancer because it can inhibit the growth of cancer cells by binding to estrogen receptors and blocking estrogen-induced cell proliferation. Tibolone also stimulates angiogenesis, which is the formation of new blood vessels in order to provide nutrients and oxygen to growing tissue. It has been shown that this drug inhibits the synthesis of hepg2 cells in vitro, which are involved in the production of angiogenic factors. Tibolone may also have clinical relevance as a chemopreventive agent against prostate cancer.BR> Tibolone has also been shown to stimulate sulphatase activity in vitro, which may contribute to

Formula: C₂₁H₃₀O₂

Purity: Min. 95%

Molecular weight: 314.46 g/mol

Ref: 3D-FH24140