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CAS 100239-45-0

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3β-Hydroxytibolone

Description:
3β-Hydroxytibolone, also known as tibolone, is a synthetic steroid with a structure that allows it to exhibit estrogenic, progestogenic, and androgenic properties. It is primarily used in hormone replacement therapy for postmenopausal women to alleviate symptoms such as hot flashes and to prevent osteoporosis. The compound functions by binding to estrogen receptors, thereby mimicking the effects of estrogen in the body, while also influencing progesterone and androgen receptors. Its chemical structure includes a hydroxyl group at the 3β position, which is crucial for its biological activity. 3β-Hydroxytibolone is characterized by its lipophilicity, allowing it to be readily absorbed and distributed in the body. The substance is typically administered orally and has a relatively long half-life, contributing to its sustained effects. However, like other hormone therapies, it may have side effects and contraindications, necessitating careful consideration and monitoring by healthcare professionals. Overall, 3β-Hydroxytibolone represents a significant advancement in the management of menopausal symptoms and related conditions.
Formula:C21H30O2
InChI:InChI=1S/C21H30O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,15,17-19,22-23H,5-12H2,2-3H3/t13-,15+,17-,18+,19-,20+,21+/m1/s1
InChI key:InChIKey=YLEUWNOTNJZCBN-XAAPQAIWSA-N
SMILES:C[C@H]1[C@]2([C@]3([C@@](C)([C@@](C#C)(O)CC3)CC[C@@]2(C4=C(C1)C[C@@H](O)CC4)[H])[H])[H]
Synonyms:
  • (3-beta-7-alpha-17-alpha)-3,17-Dihydroxy-7-methyl-19-norpregn-5(10)-en-20-yl-3-one]
  • (37a,17a)-3,17-Dihydroxy-7-methyl-19-norpregn-5(10)-en-20-yl-3-one,
  • (3Beta,7A,17A)-3,17-Dihydroxy-7-Methyl-19-Norpregn-5(10)-En-20-Yl-3-One
  • (3β,7α,17α)-7-Methyl-19-norpregn-5(10)-en-20-yne-3,17-diol
  • 19-Norpregn-5(10)-en-20-yne-3,17-diol, 7-methyl-, (3β,7α,17α)-
  • 3-Hydroxytibolone
  • 3Ss-Hydroxytibolone
  • 3β-Hydroxytibolone
  • Org 30126
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Found 2 products.
  • 3β-Hydroxy Tibolone
    TRC
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    3β-Hydroxy Tibolone

    Controlled Product
    CAS:

    Applications A metabolite of Tibolone. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
    References Belman, S., et al.: Cancer Res., 32, 450 (1972), Shirahashi, H., et al.: Chem. Pharm. Bull., 41, 1664 (1993), Hoyte, R., et al.: Steroids, 58, 13 (1993), Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Colombo, D., et al.: Eur. J. Med. Chem., 40, 69 (2005),

    Formula:C21H30O2
    Color and Shape:White To Off-White
    Molecular weight:314.46

    Ref: TR-H964260

    5mg
    235.00€
    10mg
    420.00€
  • 3β-Hydroxy Tibolone (1mg/ml in Acetonitrile)
    TRC
    + Info

    3β-Hydroxy Tibolone (1mg/ml in Acetonitrile)

    Controlled Product
    CAS:
    Formula:C21H30O2
    Color and Shape:Single Solution
    Molecular weight:314.46

    Ref: TR-KIT5365

    1x1ml
    1,012.00€