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Irinotecan hydrochloride

CAS 100286-90-6: Irinotecan hydrochloride

Description:Irinotecan hydrochloride is a semi-synthetic derivative of camptothecin, primarily used as a chemotherapeutic agent in the treatment of various cancers, particularly colorectal cancer. It functions as a topoisomerase I inhibitor, interfering with DNA replication and transcription, which ultimately leads to cancer cell death. The compound is typically administered intravenously and is known for its effectiveness in combination therapies. Irinotecan hydrochloride is characterized by its solubility in water, which facilitates its formulation for clinical use. The substance has a complex molecular structure, featuring a lactone ring that is crucial for its pharmacological activity. Common side effects associated with irinotecan include diarrhea, nausea, and myelosuppression, necessitating careful monitoring during treatment. Its pharmacokinetics involve metabolism primarily by the liver, with active metabolites contributing to its therapeutic effects and toxicity. Overall, irinotecan hydrochloride represents a significant advancement in cancer therapy, offering a targeted approach to treatment while highlighting the importance of managing its side effects.

Formula:C33H38N4O6·ClH

InChI:InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1

InChI key:InChIKey=GURKHSYORGJETM-WAQYZQTGSA-N

SMILES:Cl.O=C(OC=1C=CC2=NC=3C4=CC5=C(C(=O)N4CC3C(=C2C1)CC)COC(=O)C5(O)CC)N6CCC(N7CCCCC7)CC6

  • Synonyms:
  • (19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate hydrochloride
  • (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate
  • (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate hydrochloride (1:1)
  • (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate hydrochloride trihydrate
  • (S)-4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1h-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester
  • (S)-[1,4'-Bipiperidine]-1'-Carboxylic Acid, 4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1h-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester Hydrochloride
  • 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic acid deriv.
  • 7-Ethyl-10-[[4-(1-piperidyl)-1-piperidyl]carbonyloxy]camptothecin hydrochloride
  • Campto
  • Camptosar
  • See more synonyms
  • Camptothecin 11
  • Camptothecin 11 hydrochloride
  • Cpt 11
  • Irinotecan, Hydrochloride
  • Topotecin
  • Topotecin Hydrochloride
  • Topotesin
  • U 101440E
  • [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride (1:1)
  • [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride
  • [1,4′-Bipiperidine]-1′-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, (S)-
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Irinotecan hydrochloride

CAS:100286-90-6

Ref: 02-J60743

50mgTo inquire
250mgTo inquire
Estimated delivery in United States, on Wednesday 26 Feb 2025
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Irinotecan Hydrochloride

CAS:100286-90-6

Ref: TM-T0486L

10mg35.00 €
25mg52.00 €
50mg69.00 €
100mg95.00 €
200mg136.00 €
500mg268.00 €
1mL*10mM (DMSO)74.00 €
Estimated delivery in United States, on Tuesday 4 Mar 2025
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Irinotecan HCl

CAS:100286-90-6

Ref: 4Z-I-182

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50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Irinotecan Hydrochloride

CAS:100286-90-6

Ref: BP-BP0768

20mg48.00 €
100mg82.00 €
1000mg133.00 €
Estimated delivery in United States, on Friday 7 Mar 2025
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Ref: 4Z-I-1829

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10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Irinotecan hydrochloride anhydrous

CAS:100286-90-6

Ref: 3D-FI73263

1g762.00 €
2g1,417.00 €
5g2,999.00 €
250mg251.00 €
500mg460.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
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