CAS 10030-78-1

N2-Methylguanine

Description:

N2-Methylguanine is a modified nucleobase that is a derivative of guanine, one of the four primary bases found in DNA and RNA. It is characterized by the presence of a methyl group attached to the nitrogen atom at the second position of the guanine structure. This modification can influence the base pairing properties and stability of nucleic acids, potentially leading to mutations during DNA replication. N2-Methylguanine is often studied in the context of its role as a DNA adduct, which can arise from exposure to certain alkylating agents or environmental carcinogens. The presence of this compound in DNA can disrupt normal base pairing, leading to misincorporation of bases during replication and ultimately contributing to genetic instability. Additionally, N2-Methylguanine is of interest in the field of cancer research, as its formation is associated with the mutagenic effects of various chemical agents. Understanding its characteristics and behavior is crucial for elucidating mechanisms of mutagenesis and developing strategies for cancer prevention and treatment.

Formula: C₆H₇N₅O

InChI: InChI=1S/C6H7N5O/c1-7-6-10-4-3(5(12)11-6)8-2-9-4/h2H,1H3,(H3,7,8,9,10,11,12)

InChI key: InChIKey=SGSSKEDGVONRGC-UHFFFAOYSA-N

SMILES: O=C1C2=C(NC(NC)=N1)N=CN2

Synonyms:

• 1,9-Dihydro-2-(methylamino)-6H-purin-6-one
• 2-(Methylamino)-1H-purin-6(7H)-one
• 2-(Methylamino)-3,7-dihydropurin-6-one
• 2-(Methylamino)-6,7-dihydro-3H-purin-6-one
• 2-(Methylamino)-6,9-dihydro-1H-purin-6-one
• 2-(Methylamino)-6-hydroxypurine
• 2-(methylamino)-3,5-dihydro-6H-purin-6-one
• 2-(methylamino)-3,7-dihydro-6H-purin-6-one
• 2-Methylamino-6-oxopurine
• 2-Methylguanine
• 2-Monomethylamino-6-hydroxypurine
• 6-Hydroxy-2-(methylamino)purine
• 6H-Purin-6-one, 1,7-dihydro-2-(methylamino)-
• 6H-Purin-6-one, 1,9-dihydro-2-(methylamino)-
• Guanine, N-methyl-
• Guanine, N-methyl- (VAN)
• N2-Methylguanine
• N²-Methylguanine
• Nsc 90400

6H-Purin-6-one, 1,9-dihydro-2-(methylamino)-

CAS: 10030-78-1

Formula: C₆H₇N₅O

Purity: 97%

Color and Shape: Solid

Molecular weight: 165.1527

Ref: IN-DA0001J1

2-(Methylamino)-1H-Purin-6(7H)-One

CAS: 10030-78-1

2-(Methylamino)-1H-Purin-6(7H)-One

Purity: 98%

Molecular weight: 165.15g/mol

Ref: 54-OR1026443

N2-methylguanine

CAS: 10030-78-1

N2-methylguanine

Purity: ≥98%

Molecular weight: 165.15g/mol

Ref: 54-BUP01566

N2-methylguanine

CAS: 10030-78-1

N2-methylguanine (N2-methylguanine) is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.

Formula: C₆H₇N₅O

Purity: 99.86%

Color and Shape: Solid

Molecular weight: 165.15

Ref: TM-T13791

2-(Methylamino)-1H-purin-6(7H)-one

CAS: 10030-78-1

2-Aminopurine is a chemotherapeutic agent that has been used in the treatment of humans for over 30 years. It is an inhibitor of viral replication and is genotoxic. 2-Aminopurine inhibits the synthesis of nucleic acids by reacting with dna template and forming crosslinks between the bases, which prevents DNA polymerase from binding to the template strand. This drug also inhibits viral replication in cells by causing oxidative injury to the genome, which leads to mutations. 2-Aminopurine is used therapeutically as a cytostatic agent in combination with other drugs such as doxorubicin or vincristine. This drug has been shown to be carcinogenic in animal studies, but there are no data on human carcinogenicity.

Formula: C₆H₇N₅O

Purity: Min. 95%

Molecular weight: 165.16 g/mol

Ref: 3D-KAA03078

2-(Methylamino)-1H-purin-6(7H)-one

CAS: 10030-78-1

Formula: C₆H₇N₅O

Purity: 97%

Molecular weight: 165.156

Ref: 10-F222932

2-(Methylamino)-6,7-dihydro-3H-purin-6-one

Controlled Product

CAS: 10030-78-1

Applications 2-(methylamino)-6,7-dihydro-3H-purin-6-one (cas# 10030-78-1) is a useful research chemical.

Formula: C₆H₇N₅O

Color and Shape: Neat

Molecular weight: 165.153

Ref: TR-M286828