CAS 100306-33-0

(R)-(+)-3-chloro 1-phenyl-1-propanol

Description:

(R)-(+)-3-chloro-1-phenyl-1-propanol is an organic compound characterized by its chiral nature, which is indicated by the (R)- configuration. This compound features a propanol backbone with a phenyl group and a chlorine substituent at the third carbon position. It is typically a colorless to pale yellow liquid with a characteristic odor. The presence of the chlorine atom introduces polar characteristics, influencing its solubility in various solvents; it is generally more soluble in organic solvents than in water. The compound's chirality can lead to different biological activities depending on the enantiomer, making it of interest in pharmaceutical applications. Its synthesis often involves chiral pool strategies or asymmetric synthesis methods. Additionally, (R)-(+)-3-chloro-1-phenyl-1-propanol may participate in various chemical reactions, including nucleophilic substitutions and reductions, making it a versatile intermediate in organic synthesis. Safety data should be consulted for handling and storage, as with any chemical substance, to ensure proper precautions are taken.

Formula: C₉H₁₁ClO

InChI: InChI=1/C9H11ClO/c10-7-6-9(11)8-4-2-1-3-5-8/h1-5,9,11H,6-7H2/t9-/m1/s1

SMILES: c1ccc(cc1)[C@@H](CCCl)O

Synonyms:

• (1R)-3-Chloro-1-phenyl-propan-1-ol
• 3-Chloro-1-Phenylpropan-1-Ol
• (R)-(+)-3-Chloro-1-phenylpropanol
• (R)-(+)-3-Chloro-1-phenyl-1-propanol
• (r)-(+)-α-(2-chloroethyl)benzyl alcohol
• α-(2-chloroethyl)benzyl alcohol
• (R)-3-CHLORO-1-PHENYL-PROPAN-1-OL
• R(+)-ALPHA-(2-CHLOROETHYL)BENZYL ALCOHOL
• α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-3-Chloro-1-phenylpropanol
• ALPHA-(2-CHLOROETHYL)-BENZYL ALCOHOL
• (R)-(+)-3-CHLORO-1-PHENYL-1-PROPANOL, 98 % (99% EE/GLC)

Benzenemethanol, α-(2-chloroethyl)-, (αR)-

CAS: 100306-33-0

Formula: C₉H₁₁ClO

Purity: 98%

Color and Shape: Solid

Molecular weight: 170.6360

Ref: IN-DA0001KD

(R)-(+)-3-Chloro-1-phenyl-1-propanol

CAS: 100306-33-0

(R)-(+)-3-Chloro-1-phenyl-1-propanol

Purity: 98%

Molecular weight: 170.64g/mol

Ref: 54-OR74723

Atomoxetine Impurity 19 (R-Isomer)

CAS: 100306-33-0

Formula: C₉H₁₁ClO

Molecular weight: 170.64

Ref: 4Z-A-2540

(R)-(+)-3-Chloro-1-phenyl-1-propanol

CAS: 100306-33-0

Formula: C₉H₁₁ClO

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 170.64

Ref: 3B-C2423

(R)-(+)-3-Chloro-1-phenyl-1-propanol

CAS: 100306-33-0

Applications Intermediate in the preparation of (S)-Norfluoxetine
References Zhang, P., et al.: Bioorg. Med. Chem. Lett., 18, 6067 (2008), Graves, A., et al.: J. Mol. Biol., 377, 914 (2008), Cashman, J., et al.: Bioorg. Med. Chem., 17, 337 (2009),

Formula: C₉H₁₁ClO

Color and Shape: Off White Powder

Molecular weight: 170.64

Ref: TR-C379596

(R)-(+)-3-Chloro-1-phenylpropanol

CAS: 100306-33-0

Formula: C₉H₁₁ClO

Purity: 97%

Color and Shape: Solid

Molecular weight: 170.64

Ref: 10-F040284

(R)-3-Chloro-1-phenylpropan-1-ol

CAS: 100306-33-0

Formula: C₉H₁₁ClO

Molecular weight: 170.64

Ref: ST-EA-CP-A30030

(R)-(+)-3-Chloro-1-phenyl-1-propanol

CAS: 100306-33-0

(R)-(+)-3-Chloro-1-phenyl-1-propanol is a substrate for the lactamase of bacteria. The immobilized lipase catalyzes the hydrolysis reaction in which the lactam ring is broken, yielding a propiophenone intermediate. This intermediate can be converted to (S)-(+)-3-chloro-1-phenylpropanol by treatment with an alcohol oxidase or by hydrolysis with hydrogen peroxide. The product has been shown to have antidepressant activity and may modulate the dry weight of bacteria. In vivo studies show that this compound has a high concentration in rats and mice, but it is not active in humans.

Formula: C₉H₁₁ClO

Purity: Min. 95%

Color and Shape: White To Yellow Solid

Molecular weight: 170.64 g/mol

Ref: 3D-FC19993