CAS 100324-63-8

25-DESACETYL RIFABUTIN

Description:

25-Desacetyl Rifabutin, with the CAS number 100324-63-8, is a derivative of rifabutin, an antibiotic primarily used in the treatment of tuberculosis and certain mycobacterial infections. This compound is characterized by its structural modification, which involves the removal of an acetyl group from rifabutin, resulting in altered pharmacological properties. It exhibits antibacterial activity, particularly against Mycobacterium avium complex, and is often utilized in patients with HIV/AIDS who are at risk for opportunistic infections. The substance is known for its ability to inhibit bacterial RNA synthesis by binding to the bacterial DNA-dependent RNA polymerase. Additionally, 25-desacetyl rifabutin may have different bioavailability and metabolic pathways compared to its parent compound, influencing its therapeutic efficacy and safety profile. As with many antibiotics, resistance can develop, necessitating careful monitoring of its use in clinical settings. Overall, 25-desacetyl rifabutin represents an important component in the arsenal against mycobacterial diseases, particularly in immunocompromised populations.

Formula: C₄₄H₆₀N₄O₁₀

InChI: InChI=1/C44H60N4O10/c1-11-23(4)48-18-16-44(17-19-48)46-32-29-30-38(52)27(8)40-31(29)41(54)43(9,58-40)57-20-15-28(56-10)24(5)36(50)26(7)37(51)25(6)35(49)21(2)13-12-14-22(3)42(55)45-34(39(30)53)33(32)47-44/h12-15,20-21,23-26,28,35-37,47,49-52H,11,16-19H2,1-10H3,(H,45,55)/b13-12+,20-15+,22-14-/t21-,23?,24+,25+,26-,28-,35-,36+,37?,43-/m0/s1

Synonyms:

• 25-O-Deacetyl Rifabutin
• 25-O-Deacetylrifamycin
• (9S,12E,14S,15S,16S,17R,19R,20S,21S)-6,16,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(1-methylpropyl)-26H-spiro[9,4-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidine]-5,10,26(3H,9H)-trione

25-O-Deacetyl Rifabutin

CAS: 100324-63-8

Formula: C₄₄H₆₀N₄O₁₀

Color and Shape: Solid

Molecular weight: 804.9680

Ref: IN-DA0001MJ

Rifabutin EP Impurity E

CAS: 100324-63-8

Formula: C₄₄H₆₀N₄O₁₀

Color and Shape: Purple Solid

Molecular weight: 804.98

Ref: 4Z-R-333

25-O-Deacetyl Rifabutin

Controlled Product

CAS: 100324-63-8

Formula: C₄₄H₆₀N₄O₁₀

Color and Shape: Neat

Molecular weight: 804.97

Ref: TR-D198980

25-O-Deacetyl rifabutin

CAS: 100324-63-8

25-O-Deacetyl rifabutin is an antibiotic derivative, which is sourced from the semi-synthetic modification of rifabutin, a compound originally derived from the fermentation of the bacterium Amycolatopsis mediterranei. This derivative works by inhibiting bacterial RNA synthesis. It achieves this by specifically targeting the DNA-dependent RNA polymerase enzyme, which is essential for bacterial transcription. The mechanism involves binding to the beta-subunit of the polymerase, thereby blocking the elongation of the RNA chain, which ultimately leads to the death of the bacterial cell.

Formula: C₄₄H₆₀N₄O₁₀

Purity: Min. 95%

Color and Shape: Purple Powder

Molecular weight: 804.97 g/mol

Ref: 3D-AD20830

Rifabutin EP Impurity E

CAS: 100324-63-8

Formula: C₄₄H₆₀N₄O₁₀

Molecular weight: 805

Ref: ST-EA-CP-R38005