CAS 100324-81-0

Lisofylline

Description:

Lisofylline, with the CAS number 100324-81-0, is a synthetic compound that belongs to the class of xanthine derivatives. It is primarily recognized for its potential therapeutic applications, particularly in the treatment of conditions related to impaired blood flow and inflammation. Lisofylline exhibits properties that may enhance microcirculation and has been studied for its effects on various cellular processes, including anti-inflammatory and immunomodulatory activities. The compound is characterized by its ability to inhibit phosphodiesterase, leading to increased levels of cyclic AMP, which plays a crucial role in various physiological responses. Additionally, Lisofylline has been investigated for its potential neuroprotective effects and its role in promoting tissue repair. Its pharmacological profile suggests a multifaceted mechanism of action, making it a subject of interest in both clinical and research settings. However, further studies are necessary to fully elucidate its efficacy and safety in various therapeutic contexts.

Formula: C₁₃H₂₀N₄O₃

InChI: InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3/t9-/m1/s1

InChI key: InChIKey=NSMXQKNUPPXBRG-SECBINFHSA-N

SMILES: O=C1C2=C(N(C)C(=O)N1CCCC[C@@H](C)O)N=CN2C

Synonyms:

• (R)-1-(5-Hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione
• (R)-Lisofylline
• (R)-Lisophylline
• 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
• 1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
• 1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-, (R)-
• 1H-Purine-2,6-dione, 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-
• 3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione
• Ct 1501R
• Lisofylline
• Lisophylline

1H-Purine-2,6-dione, 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-

CAS: 100324-81-0

Formula: C₁₃H₂₀N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 280.3229

Ref: IN-DA0001MI

(R)-1-(5-Hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione

CAS: 100324-81-0

(R)-1-(5-Hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione

Purity: 97%

Molecular weight: 280.33g/mol

Ref: 54-OR1074775

(R)-Lisofylline

CAS: 100324-81-0

(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).

Formula: C₁₃H₂₀N₄O₃

Purity: 99.50%

Color and Shape: Solid

Molecular weight: 280.32

Ref: TM-T21694

(R)-Lisofylline

Controlled Product

CAS: 100324-81-0

Applications A major metabolite of Pentoxifylline. Methylxanthine that inhibits production of phosphatidic acid during the inflammatory response. Immunomodulator.
References Clarke, E., et al.: Cancer Res., et al.: 56, 105 (1996), Itani, S., et al.: Metabolism, 50, 553 (2001), Itani, S., et al.: Diabetes, 51, 2005(2002), Yu, C., et al.: J. Biol. Chem., 277, 50230 (2002),

Formula: C₁₃H₂₀N₄O₃

Color and Shape: Neat

Molecular weight: 280.32

Ref: TR-L469040

(R)-Lisofylline

Controlled Product

CAS: 100324-81-0

Metabolite of pentoxifylline

Formula: C₁₃H₂₀N₄O₃

Purity: Min. 95%

Molecular weight: 280.32 g/mol

Ref: 3D-FL24911