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Lercanidipine

CAS 100427-26-7: Lercanidipine

Description:Lercanidipine is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac cells, leading to vasodilation and reduced blood pressure. Lercanidipine is characterized by its lipophilicity, which enhances its absorption and allows for once-daily dosing. The substance has a relatively long half-life, contributing to its sustained antihypertensive effects. It is typically administered in the form of its hydrochloride salt, and its pharmacokinetics can be influenced by food intake, with a recommendation to take it on an empty stomach for optimal absorption. Common side effects may include peripheral edema, headache, and flushing, although it is generally well-tolerated. Lercanidipine's selectivity for vascular smooth muscle over cardiac tissue minimizes adverse effects on heart rate, making it a preferred choice in managing high blood pressure, particularly in patients with concomitant conditions.

Formula:C36H41N3O6

InChI:InChI=1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,33,37H,20-21,23H2,1-6H3

InChI key:InChIKey=ZDXUKAKRHYTAKV-UHFFFAOYSA-N

SMILES:O=C(OC)C1=C(NC(=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC2)C=3C=CC=CC3)C1C=4C=CC=C(C4)N(=O)=O)C)C

  • Synonyms:
  • Zanidip
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester
  • Lercanidipine
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester
  • Masnidipine
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester
  • (±)-2-((3,3-diphenylpropyl)(methyl)amino)-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Methyl 1,1-Dimethyl-2-[N-(3,3-diphenylpropyl)-N-methylamino]ethyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 1-[(3,3-diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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Found 4 products.

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Lercanidipine Hydrochloride

CAS:100427-26-7132866-11-6

Ref: 3B-L0282

1g231.00 €
200mg78.00 €
Estimated delivery in United States, on Wednesday 26 Feb 2025
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Lercanidipine

CAS:100427-26-7

Ref: TM-T2519

1mg40.00 €
5mg85.00 €
10mg124.00 €
25mg230.00 €
50mg354.00 €
100mg520.00 €
1mL*10mM (DMSO)103.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
discount label

Ref: IN-DA0001YU

5mg119.00 €
10mg157.00 €
25mg200.00 €
50mg337.00 €
100mg539.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS:100427-26-7

Discontinued product
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