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CAS 100490-36-6

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Tosufloxacin

Description:
Tosufloxacin is a synthetic fluoroquinolone antibiotic primarily used in veterinary medicine, particularly for treating bacterial infections in animals. It exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication and transcription. The compound is characterized by its chemical structure, which includes a bicyclic core structure typical of fluoroquinolones, along with various functional groups that enhance its antibacterial properties. Tosufloxacin is known for its favorable pharmacokinetic profile, including good oral bioavailability and tissue penetration, making it effective for systemic infections. It is generally well-tolerated, but like other antibiotics, it may cause side effects, including gastrointestinal disturbances and potential effects on the central nervous system. Due to its use in veterinary medicine, there are considerations regarding its impact on food safety and antibiotic resistance, prompting regulations on its use in food-producing animals. Overall, Tosufloxacin represents an important tool in the management of bacterial infections in veterinary practice.
Formula:C19H15F3N4O3
InChI:InChI=1S/C19H15F3N4O3/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29)
InChI key:InChIKey=WUWFMDMBOJLQIV-UHFFFAOYSA-N
SMILES:O=C1C=2C(N(C=C1C(O)=O)C3=C(F)C=C(F)C=C3)=NC(=C(F)C2)N4CC(N)CC4
Synonyms:
  • 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-
  • 1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-
  • 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-aminopyrrolidin-1-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid
  • 7-(3-Amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
  • 7-(3-Aminopyrrolidin-1-Yl)-1-(2,4-Difluorophenyl)-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid
  • 7-(3-Aminopyrrolidin-1-Yl)-1-(2,4-Difluorophenyl)-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid 4-Methylbenzenesulfonate (1:1)
  • A 61827
  • A 67107
  • Abbott 61827
  • Brn 4913117
  • See more synonyms
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