CAS 100510-33-6

Adibendan

Description:

Adibendan, with the CAS number 100510-33-6, is a chemical compound primarily recognized for its role as a selective inhibitor of the enzyme phosphodiesterase 5 (PDE5). This inhibition leads to increased levels of cyclic guanosine monophosphate (cGMP), which plays a crucial role in various physiological processes, including vasodilation. Adibendan has been studied for its potential therapeutic applications, particularly in the treatment of cardiovascular diseases and conditions related to impaired blood flow. The compound exhibits a specific binding affinity for PDE5, distinguishing it from other phosphodiesterase inhibitors. Its pharmacological profile suggests a favorable safety and efficacy balance, although detailed clinical data may be limited. As with many pharmaceutical compounds, understanding its solubility, stability, and metabolic pathways is essential for evaluating its therapeutic potential and safety in clinical settings. Further research is necessary to fully elucidate its mechanisms of action and potential applications in medicine.

Formula: C₁₆H₁₄N₄O

InChI: InChI=1/C16H14N4O/c1-16(2)10-7-12-13(8-11(10)20-15(16)21)19-14(18-12)9-3-5-17-6-4-9/h3-8H,1-2H3,(H,18,19)(H,20,21)

InChI key: InChIKey=TVLQBBHUNDMTEC-UHFFFAOYSA-N

SMILES: CC1(C)C=2C(=CC3=C(C2)NC(=N3)C=4C=CN=CC4)NC1=O

Synonyms:

• Pyrrolo[2,3-f]benzimidazol-6(3H)-one, 5,7-dihydro-7,7-dimethyl-2-(4-pyridinyl)-
• Pyrrolo[2,3-f]benzimidazol-6(1H)-one, 5,7-dihydro-7,7-dimethyl-2-(4-pyridinyl)-
• BM 14478
• 5,7-Dihydro-7,7-dimethyl-2-(4-pyridinyl)pyrrolo[2,3-f]benzimidazol-6(3H)-one
• Adibendan
• 5,7-Dihydro-7,7-dimethyl-2-(4-pyridyl)pyrrolo(2,3-f)benzimidazol-6(3H)-one
• Adibendan [INN]
• UNII-E87N3L27KX
• Adibendanum [Latin]
• 7,7-dimethyl-2-(pyridin-4-yl)-5,7-dihydroimidazo[4,5-f]indol-6(1H)-one
• Adibendanum

Adibendan

CAS: 100510-33-6

Adibendan

Purity: ≥95%

Molecular weight: 278.31g/mol

Ref: 54-BUP12283

7,7-Dimethyl-2-(pyridin-4-yl)-3H,5H,6H,7H-imidazo[4,5-F]indol-6-one

CAS: 100510-33-6

7,7-Dimethyl-2-(pyridin-4-yl)-3H,5H,6H,7H-imidazo[4,5-F]indol-6-one (DMPI) is a selective inhibitor of ACAT. It has been shown to be an effective drug for the treatment of cancer and bowel disease. DMPI inhibits fatty acid synthesis in cardiac muscle cells by binding to the enzyme ACAT. This leads to reduced fatty acids and increased energy production for cardiac cells. DMPI also has inhibitory properties on isolated heart cells and nitroprusside (NTP).

Formula: C₁₆H₁₄N₄O

Purity: Min. 95%

Molecular weight: 278.31 g/mol

Ref: 3D-AEA51033

Adibendan

CAS: 100510-33-6

Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.

Formula: C₁₆H₁₄N₄O

Purity: 99.52% - >99.99%

Color and Shape: Solid

Molecular weight: 278.31

Ref: TM-T23638