CAS 1005342-46-0

LCL-161

Description:

LCL-161 is a small molecule that acts as a selective inhibitor of the inhibitor of apoptosis proteins (IAPs), which are a family of proteins that regulate apoptosis (programmed cell death) and are often overexpressed in various cancers. By inhibiting IAPs, LCL-161 promotes apoptosis in cancer cells, making it a potential therapeutic agent in oncology. The compound has been studied for its ability to enhance the efficacy of other anticancer treatments, particularly in combination therapies. LCL-161 is characterized by its specific binding affinity to IAPs, leading to the activation of caspases, which are crucial enzymes in the apoptotic pathway. Additionally, it has shown promise in preclinical studies for various cancer types, including hematological malignancies and solid tumors. Its pharmacological profile includes considerations of bioavailability, metabolism, and potential side effects, which are critical for its development as a therapeutic agent. As research continues, LCL-161 may contribute to novel cancer treatment strategies, particularly in cases where traditional therapies have limited effectiveness.

Propanamide, N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-, (2S)-

CAS: 1005342-46-0

Formula: C₂₆H₃₃FN₄O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 500.6286

Ref: IN-DA00029J

LCL161

CAS: 1005342-46-0

LCL161

Purity: ≥98%

Molecular weight: 500.63g/mol

Ref: 54-BUP09749

LCL161

CAS: 1005342-46-0

LCL161 is a SMAC mimetic, an IAP antagonist with oral activity that inhibits XIAP and cIAP1. LCL161 has potential antitumor activity. Cost-effective and quality-assured.

Formula: C₂₆H₃₃FN₄O₃S

Purity: 99.13% - 99.87%

Color and Shape: Solid

Molecular weight: 500.63

Ref: TM-T2080

LCL 161

Controlled Product

CAS: 1005342-46-0

Formula: C₂₆H₃₃FN₄O₃S

Color and Shape: Neat

Molecular weight: 500.629

Ref: TR-L270000

LCL 161

CAS: 1005342-46-0

Second mitochondrial activator of caspase (SMAC) mimetic, IAP inhibitor

Formula: C₂₆H₃₃FN₄O₃S

Purity: Min. 95%

Molecular weight: 500.63 g/mol

Ref: 3D-FL103735