CAS 1006376-60-8

(αS)-α-(Chloromethyl)-3,4-difluorobenzenemethanol

Description:

(αS)-α-(Chloromethyl)-3,4-difluorobenzenemethanol is a chemical compound characterized by its unique structural features, including a chloromethyl group and two fluorine atoms attached to a benzene ring. The presence of the hydroxymethyl group indicates that it is an alcohol, which can participate in hydrogen bonding, influencing its solubility and reactivity. The chirality of the compound, denoted by the (αS) configuration, suggests that it exists as a specific enantiomer, which can have distinct biological and chemical properties compared to its mirror image. The difluorobenzene moiety contributes to the compound's electronic properties, potentially enhancing its reactivity in nucleophilic substitution reactions. Additionally, the chloromethyl group can serve as a reactive site for further chemical modifications. Overall, this compound may find applications in pharmaceuticals or agrochemicals, where specific stereochemistry and functional groups are crucial for activity. Its safety and handling would require consideration of the chloromethyl and fluorine substituents, which can pose health and environmental risks.

Formula: C₈H₇ClF₂O

InChI: InChI=1S/C8H7ClF2O/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,12H,4H2/t8-/m1/s1

InChI key: InChIKey=RYOLLNVCYSUXCP-MRVPVSSYSA-N

SMILES: [C@H](CCl)(O)C1=CC(F)=C(F)C=C1

Synonyms:

• (1S)-2-Chloro-1-(3,4-difluorophenyl)ethan-1-ol
• (1S)-2-Chloro-1-(3,4-difluorophenyl)ethanol
• (αS)-α-(Chloromethyl)-3,4-difluorobenzenemethanol
• Benzenemethanol, α-(chloromethyl)-3,4-difluoro-, (αS)-
• (S)-2-Chloro-1-(3,4-difluorophenyl)ethanol

Benzenemethanol, α-(chloromethyl)-3,4-difluoro-, (αS)-

CAS: 1006376-60-8

Formula: C₈H₇ClF₂O

Purity: 97%

Color and Shape: Liquid

Molecular weight: 192.5904

Ref: IN-DA0002J3

(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol

CAS: 1006376-60-8

(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol

Formula: C₈H₇ClF₂O

Purity: 99%

Color and Shape: clear. almost colourless. viscous liquid

Molecular weight: 192.59g/mol

Ref: 54-PC421194

Ticagrelor Impurity 54

CAS: 1006376-60-8

Formula: C₈H₇ClF₂O

Molecular weight: 192.59

Ref: 4Z-T-81172

(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol

CAS: 1006376-60-8

Purity: 98%

Molecular weight: 192.5899963

Ref: 10-F600769

(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol

Controlled Product

CAS: 1006376-60-8

Applications (S)-2-Chloro-1-(3,4-difluorophenyl)ethanol is a building block used in organic synthesis including bein an intermediate in the synthesis of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel.
References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),

Formula: C₈H₇ClF₂O

Color and Shape: Neat

Molecular weight: 192.59

Ref: TR-C365268

(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol

CAS: 1006376-60-8

Ticagrelor is an antiplatelet drug that prevents the formation of blood clots. It belongs to the class of ADP-receptor antagonists and is a prodrug that is metabolized in vivo to its active form, (S)-2-chloro-1-(3,4-difluorophenyl)ethanol. Ticagrelor inhibits platelet aggregation by binding to the P2Y12 receptor on the surface of activated platelets. Ticagrelor has been shown to be effective in reducing thrombotic events in patients with acute coronary syndrome and stable atherosclerotic disease. It also inhibits cell growth and induces apoptosis in E. coli cells. Ticagrelor binds to choline residues on the cell membrane and reacts with chlorine ions present in water, forming a catalytic system that causes a reaction at the cell membrane level. This reaction leads to inhibition of protein synthesis and death of E. coli cells via chloride

Formula: C₈H₇ClF₂O

Purity: Min. 95%

Molecular weight: 192.59 g/mol

Ref: 3D-GQB37660

(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol

CAS: 1006376-60-8

(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol is a useful organic compound for research related to life sciences. The catalog number is T66445 and the CAS number is 1006376-60-8.

Formula: C₈H₇ClF₂O

Color and Shape: Solid

Molecular weight: 192.59

Ref: TM-T66445