CAS 100648-13-3

Triclabendazole sulfoxide

Description:

Triclabendazole sulfoxide is a chemical compound derived from triclabendazole, which is primarily used as an anthelmintic agent in veterinary medicine, particularly for the treatment of liver fluke infections in livestock. The sulfoxide form is characterized by the presence of a sulfur atom bonded to an oxygen atom, which contributes to its pharmacological properties. This compound exhibits a high degree of lipophilicity, allowing it to effectively penetrate biological membranes and exert its therapeutic effects. Triclabendazole sulfoxide is known for its selective action against certain parasitic worms, making it valuable in managing parasitic infections. Its mechanism of action involves disrupting the energy metabolism of the parasites, leading to their eventual death. Additionally, it has a relatively low toxicity profile in target animals, which enhances its safety for veterinary use. The compound is typically administered orally and is subject to regulatory scrutiny to ensure its safe use in food-producing animals. Overall, triclabendazole sulfoxide plays a significant role in veterinary parasitology.

Formula: C₁₄H₉Cl₃N₂O₂S

InChI: InChI=1/C14H9Cl3N2O2S/c1-22(20)14-18-9-5-8(16)12(6-10(9)19-14)21-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)

SMILES: CS(=O)c1[nH]c2cc(c(cc2n1)Oc1cccc(c1Cl)Cl)Cl

Synonyms:

• 6-Chloro-5-(2,3-Dichlorophenoxy)-2-(Methylsulfinyl)-1H-Benzimidazole

Triclabendazole Related Compound A (5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfinyl)-1H-benzimidazole)

CAS: 100648-13-3

Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₁₄H₉Cl₃N₂O₂S

Color and Shape: Off-White Crystalline Powder

Molecular weight: 373.94503

Ref: 45-1681622

1H-Benzimidazole, 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl)-

CAS: 100648-13-3

Formula: C₁₄H₉Cl₃N₂O₂S

Purity: 97%

Color and Shape: Solid

Molecular weight: 375.6575

Ref: IN-DA0002KW

6-Chloro-5-(2,3-Dichlorophenoxy)-2-(Methylsulfinyl)-1H-Benzo[D]Imidazole

CAS: 100648-13-3

6-Chloro-5-(2,3-Dichlorophenoxy)-2-(Methylsulfinyl)-1H-Benzo[D]Imidazole

Purity: 97%

Molecular weight: 375.66g/mol

Ref: 54-OR1026124

Triclabendazole sulfoxide

CAS: 100648-13-3

Triclabendazole sulfoxide

Purity: ≥98%

Molecular weight: 375.66g/mol

Ref: 54-BUP07484

Triclabendazole EP Impurity A-13C-d3 (Triclabendazole S-Oxide-13C-d3)

CAS: 100648-13-3

Formula: C₁₃₁₃CH₆D₃Cl₃N₂O₂S

Color and Shape: White To Off-White Solid

Molecular weight: 379.66

Ref: 4Z-T-466

Triclabendazole EP Impurity A (Triclabendazole S-Oxide)

CAS: 100648-13-3

Formula: C₁₄H₉Cl₃N₂O₂S

Color and Shape: Off-White Solid

Molecular weight: 375.65

Ref: 4Z-T-465

Triclabendazole-sulfoxide

Controlled Product

CAS: 100648-13-3

Formula: C₁₄H₉Cl₃N₂O₂S

Color and Shape: Neat

Molecular weight: 375.66

Ref: 04-C17795020

5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfinyl)-1H-benzimidazole (Triclabendazole Sulfoxide)

CAS: 100648-13-3

Color and Shape: Neat

Ref: 86-MM0313.01

Triclabendazole sulfoxide

CAS: 100648-13-3

TCBZ-SO, a Triclabendazole metabolite, blocks ABCG2/BCRP and has anti-parasitic properties.

Formula: C₁₄H₉Cl₃N₂O₂S

Purity: 98.02%

Color and Shape: Solid

Molecular weight: 375.66

Ref: TM-T38400

Triclabendazole Sulfoxide

CAS: 100648-13-3

Applications Triclabendazole Sulfoxide is a metabolite of Triclabendazole (T774175), the only anthelmintic drug, which is active against immature, mature and adult stages of fluke.
References Whelan, M., et al.: J. Chromato., 1275, 41 (2013); Barrera, S., et al.; Antimicrob. Agent. Chemother., 56, 3535 (2012);

Formula: C₁₄H₉Cl₃N₂O₂S

Color and Shape: Colourless

Molecular weight: 375.66

Ref: TR-T773830

Triclabendazole Sulfoxide-D3

Controlled Product

CAS: 100648-13-3

Applications Triclabendazole Sulfoxide-D3 is a stable isotopically labelled metabolite of Triclabendazole (T774175), an anthelmintic.
References Wolff, K., et al.: Vet. Parasitol., 13, 145 (1983)

Formula: C₁₄H₆D₃Cl₃N₂O₂S

Color and Shape: Neat

Molecular weight: 378.68

Ref: TR-T773832

Triclabendazole EP Impurity A

CAS: 100648-13-3

Formula: C₁₄H₉Cl₃N₂O₂S

Molecular weight: 375.6

Ref: ST-EA-CP-T180001

Triclabendazole sulfoxide

CAS: 100648-13-3

Triclabendazolesulfoxide is a benzimidazole compound that binds to the ATP-binding cassette transporter, which is a protein in the liver that transports various drugs and other molecules. It is used to treat infections caused by roundworms, hookworms, and pinworms. Triclabendazolesulfoxide has been shown to have pharmacokinetic properties similar to triclabendazole, but with decreased protein binding. Triclabendazolesulfoxide has been shown to be an effective anthelmintic drug against roundworm infections in mice.

Formula: C₁₄H₉Cl₃N₂O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 375.66 g/mol

Ref: 3D-FT147007

Triclabendazole-sulfoxide 100 µg/mL in Acetonitrile

CAS: 100648-13-3

Formula: C₁₄H₉Cl₃N₂O₂S

Color and Shape: Single Solution

Molecular weight: 375.66

Ref: 04-A17795020AL-100