CAS 10074-18-7

Glycinamide ribonucleotide

Description:

Glycinamide ribonucleotide (GAR) is a biochemical compound that plays a crucial role in the purine biosynthesis pathway, specifically in the synthesis of nucleotides. It is an intermediate in the de novo synthesis of purines, which are essential for DNA and RNA synthesis. GAR is characterized by its structure, which includes a ribonucleotide moiety linked to glycinamide. This compound is typically a white to off-white solid and is soluble in water, reflecting its polar nature due to the presence of ribose and amino groups. GAR is involved in various metabolic processes and is important for cellular functions, including energy transfer and genetic information storage. Its CAS number, 10074-18-7, is a unique identifier that facilitates the identification and study of this compound in scientific literature and databases. Understanding GAR's role in metabolism can provide insights into cellular functions and potential therapeutic targets in diseases related to nucleotide metabolism.

Formula: C₇H₁₅N₂O₈P

InChI: InChI=1S/C7H15N2O8P/c8-1-4(10)9-7-6(12)5(11)3(17-7)2-16-18(13,14)15/h3,5-7,11-12H,1-2,8H2,(H,9,10)(H2,13,14,15)/t3-,5-,6-,7-/m1/s1

InChI key: InChIKey=OBQMLSFOUZUIOB-SHUUEZRQSA-N

SMILES: C(OP(=O)(O)O)[C@H]1O[C@@H](NC(CN)=O)[C@H](O)[C@@H]1O

Synonyms:

• 2-Amino-N-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)acetamide
• Acetamide, 2-amino-N-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-
• Acetamide, 2-amino-N-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 5′-(dihydrogen phosphate)
• Acetamide, 2-amino-N-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 5′-phosphate
• Glycinamide ribonucleotide
• Glycineamide Ribonucleotide
• Glycineamideribotide
• N-glycyl-5-O-phosphono-beta-D-ribofuranosylamine
• Acetamide, 2-amino-N-β-D-ribofuranosyl-, 5′-(dihydrogen phosphate)
• Acetamide, 2-amino-N-(5-O-phosphono-β-D-ribofuranosyl)-
• 2-Amino-N-(5-O-phosphono-β-D-ribofuranosyl)acetamide

Glycinamide ribonucleotide

CAS: 10074-18-7

Glycinamide ribonucleotide (GAR) is a reactive metabolite that is formed from glycinamide, which is an intermediate in the synthesis of purines. GAR has been shown to bind to intracellular targets and inhibit their enzyme activities. GAR has been shown to inhibit the activity of enzymes that are involved in the synthesis of purines, such as ribonucleotides and nucleoside phosphates. These enzymes have been found in human tissues. GAR also inhibits the polymerase chain reaction (PCR) by binding to DNA and inhibiting its replication. This drug has also been shown to be effective against bowel disease by binding to bacterial dna gyrase, dna topoisomerase, and rna synthesis.

Formula: C₇H₁₅N₂O₈P

Purity: Min. 80 Area-%

Color and Shape: Powder

Molecular weight: 286.18 g/mol

Ref: 3D-NG59700