CAS 100827-28-9

Erbstatin

Description:

Erbstatin is a chemical compound classified as a potent inhibitor of the enzyme protein tyrosine kinase, specifically targeting the epidermal growth factor receptor (EGFR). It is derived from the natural product erbstatin A, which is produced by certain strains of the bacterium Streptomyces. This compound exhibits significant anti-tumor activity, making it of interest in cancer research and therapeutic applications. Erbstatin functions by interfering with signal transduction pathways that promote cell proliferation and survival, thereby inhibiting the growth of cancer cells. Its mechanism of action involves the blockade of phosphorylation processes essential for the activation of various cellular pathways. Additionally, erbstatin has been studied for its potential effects on angiogenesis and metastasis in tumors. Due to its specificity and potency, it serves as a valuable tool in understanding the role of tyrosine kinases in cancer biology and may contribute to the development of targeted cancer therapies. However, further research is necessary to fully elucidate its pharmacological properties and therapeutic potential.

Formula: C₉H₉NO₃

InChI: InChI=1/C9H9NO3/c11-6-10-4-3-7-5-8(12)1-2-9(7)13/h1-6,12-13H,(H,10,11)/b4-3+

InChI key: InChIKey=SIHZWGODIRRSRA-ONEGZZNKSA-N

SMILES: C(=C/NC=O)\C1=C(O)C=CC(O)=C1

Synonyms:

• Formamide, N-[(1E)-2-(2,5-dihydroxyphenyl)ethenyl]-
• Formamide, N-[2-(2,5-dihydroxyphenyl)ethenyl]-, (E)-
• N-[(1E)-2-(2,5-Dihydroxyphenyl)ethenyl]formamide
• erbstatin
• Erbstatin
• N-[(E)-2-(2,5-dihydroxyphenyl)ethenyl]formamide
• Antibiotic MH 435A
• N-[2-(2,5-dihydroxyphenyl)ethenyl]formamide
• (E)-N-(2-(2,5-Dihydroxyphenyl)ethenyl)formamide

Erbstatin

CAS: 100827-28-9

Erbstatin is a tyrosine-protein kinase inhibitor. When combined with foroxymithine, it has antineoplastic activity against L-1210 leukemia.

Formula: C₉H₉NO₃

Color and Shape: Solid

Molecular weight: 179.17

Ref: TM-T24039