CAS 100898-63-3

5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine

Description:

5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine, with the CAS number 100898-63-3, is a modified nucleoside that plays a significant role in the field of molecular biology and biochemistry, particularly in the synthesis of oligonucleotides. This compound features a deoxycytidine base, which is a building block of DNA, modified at the 5' position with a dimethoxytrityl (DMT) protecting group. The DMT group is commonly used to protect the hydroxyl group during the synthesis of nucleotides, allowing for selective reactions. Additionally, the N4-acetyl modification enhances the stability and solubility of the nucleoside. This compound is typically utilized in solid-phase synthesis techniques for oligonucleotide production, where its protective groups can be selectively removed to facilitate the sequential addition of nucleotides. Its structural characteristics contribute to its utility in research and therapeutic applications, including gene therapy and the development of antisense oligonucleotides. Overall, this compound exemplifies the intricate modifications that enhance the functionality of nucleosides in biochemical applications.

Formula: C₃₂H₃₃N₃O₇

Synonyms:

• N4-Acetyl-2'-deoxy-5'-O-DMT-D-cytidine
• N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
• 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine (synthetic)
• Dmt-Ac-dC
• 5'-DMTr-N4-acetyl-2'-deoxycytidine

Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-

CAS: 100898-63-3

Formula: C₃₂H₃₃N₃O₇

Purity: 95%

Color and Shape: Solid

Molecular weight: 571.6203

Ref: IN-DA00033R

N4-Acetyl-2'-Deoxy-5'-O-Dmt-Cytidine

CAS: 100898-63-3

N4-Acetyl-2'-Deoxy-5'-O-Dmt-Cytidine

Purity: 98%

Molecular weight: 571.62g/mol

Ref: 54-OR1014216

N4-Acetyl-2''-deoxy-5''-O-DMT-cytidine

CAS: 100898-63-3

Ref: 7W-GN3309

5'-O-DMT-N4-Ac-dC

CAS: 100898-63-3

5'-O-DMT-N4-Ac-dC, or compound 7, is a deoxynucleoside for making dod-DNA with hydrophobic regions.

Formula: C₃₂H₃₃N₃O₇

Color and Shape: Solid

Molecular weight: 571.62

Ref: TM-T37147

N4-Acetyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-cytidine

CAS: 100898-63-3

N4-Acetyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-cytidine is a novel anticancer agent that is modified with a phosphoramidite. It is a nucleoside analog that selectively inhibits DNA polymerases and RNA polymerases, and therefore prevents the synthesis of DNA and RNA. N4-Acetyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-cytidine has been shown to be highly active against various cell lines in vitro, including human leukemia cells (HL60), human prostate cancer cells (PC3), human breast cancer cells (MCF7), and human mammary tumor cells (HTB6). This compound has also been shown to have antiestrogenic activity in vivo.

Formula: C₃₂H₃₃N₃O₇

Purity: Min. 98 Area-%

Molecular weight: 571.62 g/mol

Ref: 3D-W-200637

N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine

CAS: 100898-63-3

N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine is a potent and selective inhibitor of the receptor tyrosine kinases Cck-A, which is overexpressed in certain tumour cells. N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine blocks the activation of Cck-A by endothelin, thereby inhibiting the proliferation of tumour cells. This compound also has affinity for other protein kinases including receptor tyrosine kinase (RTK)s, which may be due to its tautomeric equilibrium.

Formula: C₃₂H₃₃N₃O₇

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 571.62 g/mol

Ref: 3D-NA04015