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CAS 100940-65-6

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sandramycin

Description:
Sandramycin, with the CAS number 100940-65-6, is an antibiotic compound that belongs to the class of anthracycline antibiotics. It is derived from the fermentation of certain Streptomyces species. Sandramycin exhibits potent antibacterial activity, particularly against a range of Gram-positive bacteria, and has been studied for its potential use in cancer therapy due to its ability to intercalate DNA and inhibit topoisomerase II, leading to disruption of DNA replication and transcription. The compound is characterized by its complex polycyclic structure, which contributes to its biological activity. Sandramycin's mechanism of action involves the generation of reactive oxygen species, which can induce oxidative stress in bacterial cells. Additionally, it has been investigated for its cytotoxic effects on various cancer cell lines, highlighting its dual potential as both an antibiotic and an anticancer agent. However, like many antibiotics, the development of resistance and potential side effects are important considerations in its therapeutic application.
Formula:C60H76N12O16
InChI:InChI=1/C60H76N12O16/c1-33(2)51-59(85)87-31-39(65-55(81)49-43(73)25-35-17-9-11-19-37(35)63-49)57(83)71-23-15-13-21-41(71)53(79)62-28-46(76)68(6)30-48(78)70(8)52(34(3)4)60(86)88-32-40(66-56(82)50-44(74)26-36-18-10-12-20-38(36)64-50)58(84)72-24-16-14-22-42(72)54(80)61-27-45(75)67(5)29-47(77)69(51)7/h9-12,17-20,25-26,33-34,39-42,51-52,73-74H,13-16,21-24,27-32H2,1-8H3,(H,61,80)(H,62,79)(H,65,81)(H,66,82)/t39-,40-,41+,42+,51+,52+/m1/s1
Synonyms:
  • N,N'-[12,15,31,34-tetramethyl-6,10,13,16,19,25,29,32,35,38-decaoxo-11,30-di(propan-2-yl)dotriacontahydro-2H,6H,10H,25H-dipyrido[2,1-l:2',1'-b_1_][1,17,4,7,10,13,20,23,26,29]dioxaoctaazacyclodotriacontine-7,26-diyl]bis(3-hydroxyquinoline-2-carboxamide)
  • N,N'-[(7R,11S,19aS,26R,30S,38aS)-12,15,31,34-tetramethyl-6,10,13,16,19,25,29,32,35,38-decaoxo-11,30-di(propan-2-yl)dotriacontahydro-2H,6H,10H,25H-dipyrido[2,1-l:2',1'-b_1_][1,17,4,7,10,13,20,23,26,29]dioxaoctaazacyclodotriacontine-7,26-diyl]bis(3-hydroxyquinoline-2-carboxamide)
  • Sandramycin
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