CAS 100981-43-9

Ebrotidine

Description:

Ebrotidine is a chemical compound primarily recognized for its role as a gastroprotective agent. It belongs to the class of substituted benzimidazoles and is known for its ability to inhibit gastric acid secretion, making it useful in the treatment of conditions such as peptic ulcers and gastroesophageal reflux disease (GERD). The compound exhibits a mechanism of action that involves antagonism of histamine H2 receptors, which are pivotal in regulating gastric acid production. Ebrotidine is characterized by its relatively low toxicity and favorable pharmacokinetic properties, including good oral bioavailability. Additionally, it has been studied for its potential to promote mucosal healing and its anti-inflammatory effects, which contribute to its therapeutic efficacy in gastrointestinal disorders. As with many pharmaceutical agents, the safety profile and side effects of ebrotidine are important considerations in clinical use, and ongoing research continues to explore its full therapeutic potential and applications in gastroenterology.

Formula: C₁₄H₁₇BrN₆O₂S₃

InChI: InChI=1S/C14H17BrN6O2S3/c15-10-1-3-12(4-2-10)26(22,23)19-9-18-5-6-24-7-11-8-25-14(20-11)21-13(16)17/h1-4,8-9H,5-7H2,(H,18,19)(H4,16,17,20,21)

InChI key: InChIKey=ZQHFZHPUZXNPMF-UHFFFAOYSA-N

SMILES: C(SCCN/C=N/S(=O)(=O)C1=CC=C(Br)C=C1)C=2N=C(NC(=N)N)SC2

Synonyms:

• 100981-43-9
• 4-bromo-N-[(E)-({2-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl}imino)methyl]benzenesulfonamide
• 4-bromo-N-{(E)-[(2-{[(2-carbamimidamido-1,3-thiazol-4-yl)methyl]sulfanyl}ethyl)amino]methylidene}benzenesulfonamide
• Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, (E)-
• Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-
• Ebrodin
• Fi 3542
• N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide
• N-p-Bromobenzenesulfonyl-N'-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]formamidine
• Ulsanic
• [N(E)]-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide
• benzenesulfonamide, N-[(1E)-[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-
• p-Bromo-N-[[[2-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]benzenesulfonamide

Ebrotidine

CAS: 100981-43-9

Formula: C₁₄H₁₇BrN₆O₂S₃

Purity: 98.51%

Color and Shape: Solid

Molecular weight: 477.4228

Ref: IN-DA008T3P

Ebrotidine

CAS: 100981-43-9

Ebrotidine

Purity: ≥95%

Molecular weight: 477.42g/mol

Ref: 54-BUP16319

Ebrotidine

CAS: 100981-43-9

H2 receptor antagonist; gastroprotective

Formula: C₁₄H₁₇BrN₆O₂S₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 477.43 g/mol

Ref: 3D-FE65014

Ebrotidine

Controlled Product

CAS: 100981-43-9

Stability Light Sensitive
Applications Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.
References Andrade, R.J., et al.: Hepatol., 44, 1581 (2006); Wajima, T., et al.: J. Pharma. Sci., 92, 2427 (2003); Sentellas, S.. et al.: J. Chroma., 976, 221 (2002);

Formula: C₁₄H₁₇BrN₆O₂S₃

Color and Shape: White To Off-White

Molecular weight: 477.42

Ref: TR-E320550

Ebrotidine

CAS: 100981-43-9

Ebrotidine (FI3542) is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a potent antisecretory activity and evidenced gastroprotection.

Formula: C₁₄H₁₇BrN₆O₂S₃

Purity: 97.519%

Color and Shape: Solid

Molecular weight: 477.42

Ref: TM-T15195