CAS 100981-43-9: Ebrotidine

Description: Ebrotidine is a chemical compound primarily recognized for its role as a gastroprotective agent. It belongs to the class of substituted benzimidazoles and is known for its ability to inhibit gastric acid secretion, making it useful in the treatment of conditions such as peptic ulcers and gastroesophageal reflux disease (GERD). The compound exhibits a mechanism of action that involves antagonism of histamine H2 receptors, which are pivotal in regulating gastric acid production. Ebrotidine is characterized by its relatively low toxicity and favorable pharmacokinetic properties, including good oral bioavailability. Additionally, it has been studied for its potential to promote mucosal healing and its anti-inflammatory effects, which contribute to its therapeutic efficacy in gastrointestinal disorders. As with many pharmaceutical agents, the safety profile and side effects of ebrotidine are important considerations in clinical use, and ongoing research continues to explore its full therapeutic potential and applications in gastroenterology.

Formula: C₁₄H₁₇BrN₆O₂S₃

InChI: InChI=1S/C14H17BrN6O2S3/c15-10-1-3-12(4-2-10)26(22,23)19-9-18-5-6-24-7-11-8-25-14(20-11)21-13(16)17/h1-4,8-9H,5-7H2,(H,18,19)(H4,16,17,20,21)

InChI key: InChIKey=ZQHFZHPUZXNPMF-UHFFFAOYSA-N

SMILES: O=S(=O)(N=CNCCSCC=1N=C(SC1)NC(=N)N)C2=CC=C(Br)C=C2

Synonyms:

• 100981-43-9
• 4-bromo-N-[(E)-({2-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl}imino)methyl]benzenesulfonamide
• 4-bromo-N-{(E)-[(2-{[(2-carbamimidamido-1,3-thiazol-4-yl)methyl]sulfanyl}ethyl)amino]methylidene}benzenesulfonamide
• Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, (E)-
• Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-
• Ebrodin
• Fi 3542
• N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide
• N-p-Bromobenzenesulfonyl-N'-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]formamidine
• Ulsanic
• [N(E)]-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide
• benzenesulfonamide, N-[(1E)-[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-
• p-Bromo-N-[[[2-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]benzenesulfonamide
• Ebrotidine

Ebrotidine

CAS: 100981-43-9

• Formula: C₁₄H₁₇BrN₆O₂S₃
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 477.4228

Ebrotidine

CAS: 100981-43-9

H2 receptor antagonist; gastroprotective

• Formula: C₁₄H₁₇BrN₆O₂S₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 477.43 g/mol

Ebrotidine

CAS: 100981-43-9

Stability Light Sensitive Applications Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties …

• Formula: C₁₄H₁₇BrN₆O₂S₃
• Color and Shape: White To Off-White
• Molecular weight: 477.42

Ebrotidine

CAS: 100981-43-9

Ebrotidine (FI3542) is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a …

• Formula: C₁₄H₁₇BrN₆O₂S₃
• Purity: 97.5%
• Color and Shape: Solid
• Molecular weight: 477.42