CAS 100986-86-5

(+)-Ofloxacin

Description:

(+)-Ofloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity. It is primarily effective against a variety of Gram-positive and Gram-negative bacteria, making it useful in treating infections such as respiratory tract infections, urinary tract infections, and skin infections. The compound features a bicyclic core structure, which includes a quinolone moiety, and is distinguished by the presence of a fluorine atom at the C-6 position, enhancing its antimicrobial potency. (+)-Ofloxacin exhibits good oral bioavailability and is typically administered in the form of tablets or intravenous formulations. Its mechanism of action involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and repair. The substance is generally well-tolerated, though it may cause side effects such as gastrointestinal disturbances, central nervous system effects, and, in rare cases, tendonitis or tendon rupture. As with all antibiotics, appropriate use is essential to mitigate the risk of developing antibiotic resistance.

Formula: C₁₈H₂₀FN₃O₄

InChI: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m1/s1

InChI key: InChIKey=GSDSWSVVBLHKDQ-SNVBAGLBSA-N

SMILES: O=C1C=2C3=C(C(=C(F)C2)N4CCN(C)CC4)OC[C@@H](C)N3C=C1C(O)=O

Synonyms:

• (+)-Ofloxacin
• (3R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
• (3R)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
• (R)-(+)-Ofloxacin
• (R)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3R)-
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3R)- (9CI)
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (R)-
• <span class="text-smallcaps">D</span>-Ofloxacin
• Dextrofloxacin
• Dr 3354

R-Ofloxacin ((R)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid)

CAS: 100986-86-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₈H₂₀FN₃O₄

Color and Shape: Yellow Pale Yellow Powder

Molecular weight: 361.14378

Ref: 45-1478083

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3R)-

CAS: 100986-86-5

Formula: C₁₈H₂₀FN₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 361.3675

Ref: IN-DA0003DP

(R)-Ofloxacin (d-Levofloxacin)

CAS: 100986-86-5

Formula: C₁₈H₂₀FN₃O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 361.37

Ref: 4Z-O-034004

(R)-Ofloxacin

CAS: 100986-86-5

(R)-Ofloxacin

Purity: 98%

Molecular weight: 361.37g/mol

Ref: 54-PC111402

(R)-Ofloxacin

CAS: 100986-86-5

(R)-Ofloxacin is a R-isomer of Ofloxacin, an antibiotic used to treat a number of bacterial infections.

Formula: C₁₈H₂₀FN₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 361.37

Ref: TM-T17307

Levofloxacin EP Impurity A

CAS: 100986-86-5

Formula: C₁₈H₂₀FN₃O₄

Molecular weight: 361.37

Ref: ST-EA-CP-L17001

(R)-Ofloxacin

Controlled Product

CAS: 100986-86-5

Applications Fluorinated quinolone antibacterial. An enantiomer of Levofloxacin (L360000).
References Hwangbo, H.J. et al.: Eur. J. Pharmac. Sci., 18, 197 (203); Gascon, A.R. et al.: J. Clin. Pharmacol, 40, 869 (2000); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);

Formula: C₁₈H₂₀FN₃O₄

Color and Shape: Off-White

Molecular weight: 361.37

Ref: TR-O245740

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3R)-

CAS: 100986-86-5

Purity: 98%

Molecular weight: 361.3729858

Ref: 10-F865508