CAS 100986-89-8

Levofloxacin Q-acid

Description:

Levofloxacin Q-acid, with the CAS number 100986-89-8, is a chemical compound that is a derivative of levofloxacin, which is a fluoroquinolone antibiotic. This substance is characterized by its ability to inhibit bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication and transcription. Levofloxacin Q-acid is typically a white to off-white crystalline powder, soluble in water and various organic solvents, which facilitates its use in pharmaceutical formulations. Its molecular structure includes a bicyclic core with a fluorine atom, contributing to its broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. The compound is often utilized in the treatment of respiratory tract infections, urinary tract infections, and skin infections. Additionally, it may exhibit some degree of phototoxicity and has specific storage requirements to maintain its stability. As with other fluoroquinolones, it is essential to monitor for potential side effects, including tendonitis and effects on the central nervous system.

Formula: C₁₉H₂₀FN₃O₆

InChI: InChI=1/C13H9F2NO4/c1-5-4-20-12-9(15)8(14)2-6-10(12)16(5)3-7(11(6)17)13(18)19/h2-3,5H,4H2,1H3,(H,18,19)/t5-/m0/s1

InChI key: InChIKey=NVKWWNNJFKZNJO-YFKPBYRVSA-N

SMILES: O=C1C=2C=3N(C=C1C(O)=O)[C@@H](C)COC3C(F)=C(F)C2

Synonyms:

• (3S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
• (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
• (S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
• (S)-9,10-Difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-
• 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-(3S)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
• 9,10-Difluoro-3-(S)-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
• 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
• Levofloxacin Q-acid
• Levofloxacin acid
• Levofluorocarboxylic acid
• Levofloxacin carboxylic acid
• 9,10-DIFLUORO-2,3-DIHYDRO-3-(S)-METHYL-7-OXO-7H-PY
• 8,9-difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid
• S(-)-9,10-DIFL-2,3-DIHYDRO-3-ME-7H-PYRI&
• (-)-9,10-DIFLUORO-3(S)-METHL-7-OXO-2,3-DIHYDRO-7H-PRYIDO[1,2,3-DE]1,2-BENZOX-AZINE-6-CARBOXYLICACID

Levofloxacin Q-Acid

CAS: 100986-89-8

Formula: C₁₃H₉F₂NO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 281.21

Ref: 3B-L0238

LEVOFLOXACIN IMPURITY F CRS

CAS: 100986-89-8

LEVOFLOXACIN IMPURITY F CRS

Ref: 41-Y0002084

Levofloxacin Related Compound B ((S)-9,10,difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid)

CAS: 100986-89-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₃H₉F₂NO₄

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 281.04996

Ref: 45-1362125

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-

CAS: 100986-89-8

Formula: C₁₃H₉F₂NO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 281.2117

Ref: IN-DA0003DO

Levofloxacin carboxylic acid

CAS: 100986-89-8

Levofloxacin carboxylic acid

Purity: 98%

Molecular weight: 281.21g/mol

Ref: 54-PC109150

Levofloxacin EP Impurity F (Levofloxacin USP Related Compound B)

CAS: 100986-89-8

Formula: C₁₃H₉F₂NO₄

Color and Shape: Off-White Solid

Molecular weight: 281.21

Ref: 4Z-L-232

(S)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid

CAS: 100986-89-8

Color and Shape: Neat

Ref: 86-MM0846.01

(S)-9,10-Difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

CAS: 100986-89-8

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 281.2149963378906

Ref: 10-F222352

(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido-[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

CAS: 100986-89-8

(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido-[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid is a fluoroquinolone compound used in biochemical experiments and drug synthesis research.

Formula: C₁₃H₉F₂NO₄

Purity: 99.10%

Color and Shape: Solid

Molecular weight: 281.21

Ref: TM-T65424

Levofloxacin EP Impurity F

CAS: 100986-89-8

Formula: C₁₃H₉F₂NO₄

Molecular weight: 281.21

Ref: ST-EA-CP-L17006

Levofloxacin Carboxylic Acid (Levofloxacin Difluoro Impurity)

Controlled Product

CAS: 100986-89-8

Impurity Levofloxacin USP Related Compound B
Applications Levofloxacin intermediate.
References Liu, Bo; Y., et al.: Bioorg. Med. Chem., 13, 2451 (2005), Lalitha D., et al.: J. Pharm. Biomed. Anal., 50, 710 (2009),

Formula: C₁₃H₉F₂NO₄

Color and Shape: Neat

Molecular weight: 281.21

Ref: TR-L360250

Levofloxacin carboxylic acid

CAS: 100986-89-8

Levofloxacin is a synthetic molecule with an asymmetric carbon atom in its heterocycle. It is synthesized by reacting chloroform with 2-fluoro-5-nitrobenzaldehyde, which reacts further with sodium hydroxide and hydrochloric acid to form the levofloxacin carboxylic acid. Impurities can be found in the reaction product due to chlorine atoms that are formed during the synthesis. The amount of impurities present in the final product can be determined using a titration method or through HPLC analysis. Levofloxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.

Formula: C₁₃H₉F₂NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 281.21 g/mol

Ref: 3D-IL24882