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CAS 100992-60-7

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epibestatin hydrochloride

Description:
Epibestatin hydrochloride is a synthetic peptide and a potent inhibitor of the enzyme dipeptidyl peptidase IV (DPP-IV), which plays a crucial role in glucose metabolism and is a target for diabetes treatment. This compound is derived from the natural peptide bestatin and is characterized by its ability to enhance insulin secretion and improve glycemic control. As a hydrochloride salt, it is typically more soluble in water, facilitating its use in pharmaceutical formulations. Epibestatin hydrochloride exhibits a specific structure that contributes to its biological activity, including a sequence of amino acids that allows for effective binding to the DPP-IV enzyme. Its pharmacological profile suggests potential applications in managing type 2 diabetes and possibly other metabolic disorders. Additionally, like many peptides, it may have a relatively short half-life in circulation, necessitating careful consideration of dosing regimens in therapeutic contexts. Overall, epibestatin hydrochloride represents a significant advancement in the development of DPP-IV inhibitors for diabetes management.
Formula:C16H25ClN2O4
InChI:InChI=1/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13-,14-;/m1./s1
SMILES:CC(C)C[C@H](C(=O)O)N=C([C@@H]([C@@H](Cc1ccccc1)N)O)O.Cl
Synonyms:
  • (2R)-2-[[(2R,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid hydrochloride
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