CAS 10106-41-9

17-α,21-dihydroxy-16-α-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate

Description:

17-α,21-dihydroxy-16-α-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate, commonly known as dexamethasone acetate, is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is characterized by its steroid structure, which includes a cyclopentanoperhydrophenanthrene core, modified with hydroxyl groups at the 17 and 21 positions and an acetate group at the 21 position. This compound exhibits high potency and a long duration of action, making it effective in treating various conditions such as allergies, autoimmune diseases, and certain cancers. Dexamethasone acetate is often administered via injection or topical formulations, and it is known for its ability to suppress the immune response and reduce inflammation. Its pharmacological effects are mediated through the glucocorticoid receptor, leading to alterations in gene expression. As with other corticosteroids, it may have side effects, including potential impacts on metabolism, immune function, and electrolyte balance, necessitating careful monitoring during therapeutic use.

Formula: C₂₄H₃₀O₅

InChI: InChI=1/C24H30O5/c1-14-11-20-18-6-5-16-12-17(26)7-9-22(16,3)19(18)8-10-23(20,4)24(14,28)21(27)13-29-15(2)25/h7-9,12,14,18,20,28H,5-6,10-11,13H2,1-4H3/t14-,18-,20+,22+,23+,24+/m1/s1

InChI key: InChIKey=AAPZMQVULRVUEU-PYAFTSMNSA-N

SMILES: C[C@@]12[C@]([C@]3(C(=CC1)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])(C[C@@H](C)[C@@]2(C(COC(C)=O)=O)O)[H]

Synonyms:

• (16Alpha)-17-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4,9(11)-Trien-21-Yl Acetate
• (16α)-21-(Acetyloxy)-17-hydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione
• Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16α-methyl-, 21-acetate
• Pregna-1,4,9(11)-triene-3,20-dione, 21-(acetyloxy)-17-hydroxy-16-methyl-, (16α)-
• "17,21-Dihydroxy-16-β-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate"
• Dexamethasone impurity H
• 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
• 2-((8S,10S,13S,14S,16R,17R)-17
• Dexamethasone Acetate Impurity H
• 17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate
• 21-Acetoxy-17-hydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione
• 17-alpha,21-dihydroxy-16-alpha-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate
• (16α)-17-Hydroxy-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate
• Dexamethasone Acetate Impurity 8（Dexamethasone Acetate EP Impurity H）
• Dexamethasone Acetate EP Impurity H
• Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16.alpha.-methyl-, 21-acetate
• Pregnatriene acetate
• Dexamethasone EP Imp H
• 17α, 21-dihydroxy-16α-methyl-1, 4 ,9(11)-pregnatriene-3, 20-dione 21-acetate
• 17-HYDROXY-16-ALPHA-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIEN-21-YL ACETATE
• 21-Acetyloxy-17-hydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione
• 2-((10S,13S,14S,16R,17R)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
• Dexamethasone impurity 2/Dexamethasone EP Impurity H
• 17-hydroxy-16α-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate
• Dexamethasone Impurity 8(Dexamethasone EP Impurity H)

Dexamethasone EP Impurity H

CAS: 10106-41-9

Formula: C₂₄H₃₀O₅

Color and Shape: Pale Yellow Solid

Molecular weight: 398.50

Ref: 4Z-D-3633

17-Hydroxy-16α-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl Acetate

CAS: 10106-41-9

Formula: C₂₄H₃₀O₅

Color and Shape: Neat

Molecular weight: 398.49

Ref: 86-MM0445.08

17,21-Dihydroxy-16a-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate

Controlled Product

CAS: 10106-41-9

Applications 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate is an intermediate in the synthesis of Mometasone Furoate (M490000), a tropical corticosteroid used as an anti-inflammatory agent.
References Spangler, M., et al.: Chromatograph., 54, 329 (2001); Reeves, E.K., et al.: Bioorg. Med. Chem., 21, 2241 (2013);

Formula: C₂₄H₃₀O₅

Color and Shape: White To Light Yellow

Molecular weight: 398.49

Ref: TR-D453275

16α-Methyl-d3-9,11-dehydro Prednisolone 21-Acetate

Controlled Product

CAS: 10106-41-9

Applications Intermediate in the preparation of non-hormonal steroid modulators.

Formula: C₂₄H₂₇D₃O₅

Color and Shape: Neat

Molecular weight: 401.51

Ref: TR-M295312

Dexamethasone Acetate EP Impurity H

CAS: 10106-41-9

Formula: C₂₄H₃₀O₅

Molecular weight: 398.5

Ref: ST-EA-CP-D17038

17-α,21-Dihydroxy-16-a-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate

Controlled Product

CAS: 10106-41-9

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Formula: C₂₄H₃₀O₅

Purity: Min. 95%

Molecular weight: 398.49 g/mol

Ref: 3D-FA46287