CAS 1011-65-0

5-Indolecarboxylic acid methyl ester

Description:

5-Indolecarboxylic acid methyl ester, also known as methyl 5-indolecarboxylate, is an organic compound characterized by its indole structure, which consists of a fused benzene and pyrrole ring. This compound features a carboxylic acid group that is esterified with a methyl group, contributing to its reactivity and solubility properties. It is typically a white to off-white solid or a viscous liquid, depending on the specific conditions. The presence of the indole moiety imparts unique biological activities, making it of interest in medicinal chemistry and drug development. The compound is soluble in organic solvents such as ethanol and dichloromethane, but has limited solubility in water. Its synthesis often involves the esterification of 5-indolecarboxylic acid with methanol, and it can be utilized in various chemical reactions, including as a building block for more complex organic molecules. Safety data should be consulted for handling, as with all chemical substances, to ensure proper precautions are taken.

Formula: C₁₀H₉NO₂

InChI: InChI=1/C10H9NO2/c1-13-10(12)8-2-3-9-7(6-8)4-5-11-9/h2-6,11H,1H3

SMILES: COC(=O)c1ccc2c(cc[nH]2)c1

Synonyms:

• Indole-5-carboxylic acid methyl ester
• Methyl indole-5-carboxylate
• methyl 1H-indole-5-carboxylate
• 1H-Indole-5-carboxylic acid, methyl ester

Methyl Indole-5-carboxylate

CAS: 1011-65-0

Formula: C₁₀H₉NO₂

Purity: >98.0%(GC)

Color and Shape: White to Gray to Brown powder to crystal

Molecular weight: 175.19

Ref: 3B-I0545

Methyl indole-5-carboxylate, 97%

CAS: 1011-65-0

Reactant for biosynthesis of inhibitors of protein kinases, reactant in metal-free Friedel-Crafts alkylation, reactant in preparation of diphenylsulfonium ylides from Martin?s sulfurane, reactant in cross dehydrogenative coupling reactions, reactant in synthesis of indirubin derivatives, reactant in

Formula: C₁₀H₉NO₂

Purity: 97%

Color and Shape: Powder, White to pale cream to pale yellow

Molecular weight: 175.19

Ref: 02-L16228

1H-Indole-5-carboxylic acid, methyl ester

CAS: 1011-65-0

Formula: C₁₀H₉NO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 175.1840

Ref: IN-DA0003RH

Methyl 1H-indole-5-carboxylate

CAS: 1011-65-0

Methyl 1H-indole-5-carboxylate

Formula: C₁₀H₉NO₂

Purity: 98%

Color and Shape: light yellow solid

Molecular weight: 175.18g/mol

Ref: 54-OR10190

Methyl indole-5-carboxylate

CAS: 1011-65-0

Formula: C₁₀H₉NO₂

Molecular weight: 175.19

Ref: 7W-GK3193

Methyl indole-5-carboxylate

CAS: 1011-65-0

Methyl indole-5-carboxylate is a hdac inhibitor that has been shown to have anticancer activity. It has been shown to inhibit the growth of hCT116 cells and xenograft tumors in mice. Methyl indole-5-carboxylate is also an active analog for other anticancer agents, such as 5-azacytidine and 5-aza-2'-deoxycytidine. The drug is cytotoxic to L6 cells and increases the expression of p21 protein, which inhibits tumor cell proliferation. This compound is metabolized by cytochrome P450 enzymes into methyl indole carboxylate, which can be further converted into a reactive intermediate that binds DNA.

Formula: C₁₀H₉NO₂

Color and Shape: Powder

Molecular weight: 175.18 g/mol

Ref: 3D-FM25514

Methyl indole-5-carboxylate

CAS: 1011-65-0

Formula: C₁₀H₉NO₂

Purity: 97%

Color and Shape: Red powder

Molecular weight: 175.187

Ref: 10-F016239

Methyl Indole-5-carboxylate

Controlled Product

CAS: 1011-65-0

Formula: C₁₀H₉NO₂

Color and Shape: Neat

Molecular weight: 175.184

Ref: TR-M313485