CAS 101125-32-0

3-(4-Fluoro-phenyl)-1H-indole

Description:

3-(4-Fluoro-phenyl)-1H-indole is an organic compound characterized by its indole structure, which consists of a fused benzene and pyrrole ring. The presence of a fluorophenyl group at the 3-position of the indole ring introduces both electron-withdrawing and steric effects, influencing the compound's reactivity and interaction with biological targets. This compound is typically a solid at room temperature and may exhibit moderate solubility in organic solvents. Its fluorine substituent can enhance lipophilicity and potentially improve the compound's pharmacokinetic properties, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. The indole moiety is known for its occurrence in various natural products and its role in biological systems, including neurotransmitter function. As with many indole derivatives, 3-(4-Fluoro-phenyl)-1H-indole may exhibit diverse biological activities, including potential anti-cancer or anti-inflammatory properties, although specific biological data would depend on empirical studies. Safety and handling precautions should be observed due to the potential toxicity of fluorinated compounds.

Formula: C₁₄H₁₀FN

InChI: InChI=1/C14H10FN/c15-11-7-5-10(6-8-11)13-9-16-14-4-2-1-3-12(13)14/h1-9,16H

SMILES: c1ccc2c(c1)c(c[nH]2)c1ccc(cc1)F

Synonyms:

• 3-(4-Fluorophenyl)-Indole

1H-Indole, 3-(4-fluorophenyl)-

CAS: 101125-32-0

Formula: C₁₄H₁₀FN

Purity: 97%

Color and Shape: Solid

Molecular weight: 211.2343

Ref: IN-DA0003T2

3-(4-Fluorophenyl)-1H-indole

CAS: 101125-32-0

3-(4-Fluorophenyl)-1H-indole

Purity: 97%

Molecular weight: 211.24g/mol

Ref: 54-PC1004257

3-(4-Fluoro-phenyl)-1H-indole

CAS: 101125-32-0

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 211.23899841308594

Ref: 10-F040617

3-(4-Fluorophenyl)-1H-indole

Controlled Product

CAS: 101125-32-0

Applications 3-(4-Fluorophenyl)-1H-indole is a reagent used in the synthesis indole based sigma receptor ligands. Also used in the preparation of Fluvastatin (F601250), a synthetic HMG-CoA reductase inhibitor. Antilipemic.
References Yuan, J., et al.: Atherosclerosis, 87, 147 (1991), Tse, F.L.S., et al.: J. Clin. Pharmacol., 32, 630 (1992), Dain, J.G., et al.: Drug Metab. Disposit., 21, 567 (1993); Mesangeau, C. et al.: Eur. J. Med. Chem., 46, 5154 (2011);

Formula: C₁₄H₁₀FN

Color and Shape: Neat

Molecular weight: 211.23

Ref: TR-F598765