CAS 101312-92-9

Valnemulin

Description:

Valnemulin is a synthetic antibiotic belonging to the pleuromutilin class, primarily used in veterinary medicine for the treatment of bacterial infections in livestock, particularly in pigs. It exhibits broad-spectrum antimicrobial activity against various Gram-positive bacteria and some Gram-negative pathogens. Valnemulin functions by inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby disrupting the translation process. This mechanism makes it effective against pathogens that cause respiratory and enteric diseases in animals. The substance is typically administered orally or via injection, and it is known for its relatively low toxicity in target species. Valnemulin is also characterized by its stability under various environmental conditions, which contributes to its efficacy in veterinary applications. However, its use raises concerns regarding antibiotic resistance and potential residues in food products, prompting regulatory scrutiny in many regions. As with all antibiotics, responsible use is essential to mitigate the risk of resistance development.

Formula: C₃₁H₅₂N₂O₅S

InChI: InChI=1S/C31H52N2O5S/c1-10-29(8)15-22(38-23(35)16-39-28(6,7)17-33-27(37)24(32)18(2)3)30(9)19(4)11-13-31(20(5)26(29)36)14-12-21(34)25(30)31/h10,18-20,22,24-26,36H,1,11-17,32H2,2-9H3,(H,33,37)/t19-,20+,22-,24-,25+,26+,29-,30+,31+/m1/s1

InChI key: InChIKey=LLYYNOVSVPBRGV-MVNKZKPCSA-N

SMILES: C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(CSC(CNC([C@@H](C(C)C)N)=O)(C)C)=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H]

Synonyms:

• (3aS,4R,5S,6S,8R,9R,9aR)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl {[2-methyl-1-(valylamino)propan-2-yl]sulfanyl}acetate
• (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl {[1,1-dimethyl-2-(D-valylamino)ethyl]sulfanyl}acetate
• (4R,5S,6S,8R,9aR,10R)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl {[2-methyl-1-(D-valylamino)propan-2-yl]sulfanyl}acetate
• 2-[[2-[[(2R)-2-Amino-3-methyl-1-oxobutyl]amino]-1,1-dimethylethyl]thio]acetic Acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyldecahydro-5-hydroxy-4,6,9,10- tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl Ester
• 3a,9-Propano-3aH-cyclopentacyclooctene, acetic acid deriv.
• Acetic acid, 2-[[2-[[(2R)-2-amino-3-methyl-1-oxobutyl]amino]-1,1-dimethylethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, [[2-[(2-amino-3-methyl-1-oxobutyl)amino]-1,1-dimethylethyl]thio]-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, [3aS-[3aα,4β,5α,6α,8β(S*),9α,9aβ,10S*]]-
• Acetic acid, [[2-[[(2R)-2-amino-3-methyl-1-oxobutyl]amino]-1,1-dimethylethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Econor
• Valnemulin

Valnemulin Hydrochloride

CAS: 101312-92-9, 133868-46-9

Formula: C₃₁H₅₂N₂O₅S·HCl

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 601.28

Ref: 3B-V0144

Valnemulin

CAS: 101312-92-9

Valnemulin, a broad-spectrum pleuromutilin antibiotic, targets peptidyl transferase within the 50S ribosomal subunit, effectively used in veterinary medicine to address swine diseases such as B. hyodysenteriae and M. hyopneumoniae.

Formula: C₃₁H₅₂N₂O₅S

Color and Shape: Solid

Molecular weight: 564.83

Ref: TM-T84389