CAS 101314-97-0: Simvastatin sodium
Description:Simvastatin sodium is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular diseases. It functions by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver. The compound is typically presented as a white to off-white powder, which is soluble in organic solvents like methanol and ethanol but has limited solubility in water. Its molecular formula reflects a complex structure that includes a lactone ring, contributing to its pharmacological activity. Simvastatin sodium is often administered in oral form, with its efficacy enhanced when taken in the evening, aligning with the body's natural cholesterol synthesis cycle. The substance is generally well-tolerated, though it may cause side effects such as muscle pain or liver enzyme alterations in some patients. As with all medications, its use should be monitored by healthcare professionals to ensure safety and effectiveness, particularly in individuals with pre-existing conditions or those taking other medications.
Formula:C25H40O6·Na
InChI:InChI=1S/C25H40O6.Na/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);/t15-,16-,18+,19+,20-,21-,23-;/m0./s1
InChI key:InChIKey=SVIXZYADIXSPPP-OKDJMAGBSA-N
SMILES:[Na].O=C(O)CC(O)CC(O)CCC1C(C=CC2=CC(C)CC(OC(=O)C(C)(C)CC)C21)C
- Synonyms:
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, sodium salt (1:1), (βR,δR,1S,2S,6R,8S,8aR)-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monosodium salt, [1S-[1α(βS*,δS*),2α,6β,8β,8aα]]-
- Simvastatin hydroxy acid sodium salt
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, monosodium salt, (βR,δR,1S,2S,6R,8S,8aR)-
- Simvastatin sodium salt
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