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CAS 101363-10-4

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Rufloxacin

Description:
Rufloxacin is a synthetic fluoroquinolone antibiotic that exhibits broad-spectrum antibacterial activity. It is primarily used to treat various bacterial infections, particularly those caused by Gram-negative and some Gram-positive bacteria. The compound works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription, thereby preventing bacterial cell division and growth. Rufloxacin is characterized by its relatively high bioavailability and is often administered orally. Its chemical structure includes a bicyclic core with a fluorine atom, which enhances its potency and spectrum of activity compared to earlier generations of quinolones. Rufloxacin is generally well-tolerated, but like other antibiotics, it may cause side effects such as gastrointestinal disturbances, central nervous system effects, and potential tendon damage. It is important to use this antibiotic judiciously to minimize the risk of developing antibiotic resistance. As with any medication, it should be prescribed based on susceptibility patterns and individual patient factors.
Formula:C17H19ClFN3O3S
InChI:InChI=1/C17H18FN3O3S.ClH/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24;/h8-9H,2-7H2,1H3,(H,23,24);1H
InChI key:InChIKey=NJCJBUHJQLFDSW-UHFFFAOYSA-N
SMILES:O=C1C=2C3=C(C(=C(F)C2)N4CCN(C)CC4)SCCN3C=C1C(O)=O
Synonyms:
  • 7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-
  • 9-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic acid
  • 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid
  • 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride (1:1)
  • Rufloxacin [INN:BAN]
  • Rufloxacine
  • Rufloxacine [French]
  • Rufloxacino
  • Rufloxacino [Spanish]
  • Rufloxacinum
  • See more synonyms
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