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CAS 101403-24-1

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(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-Naphthalenamine(Rotigotine)

Description:
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-naphthalenamine, commonly known as Rotigotine, is a synthetic compound primarily used in the treatment of Parkinson's disease and restless legs syndrome. It acts as a dopamine receptor agonist, mimicking the effects of dopamine in the brain, which is crucial for motor control and coordination. Rotigotine is characterized by its naphthalene structure, which contributes to its lipophilicity, allowing for effective transdermal delivery. The compound exhibits a chiral center, with the (S)-enantiomer being the active form that provides therapeutic effects. Its pharmacokinetic profile includes a relatively long half-life, enabling sustained release formulations. Rotigotine is typically administered via a transdermal patch, which facilitates continuous drug delivery and minimizes fluctuations in plasma levels. The substance is also noted for its potential side effects, including nausea, dizziness, and somnolence, which are common among dopaminergic therapies. Overall, Rotigotine represents an important option in the management of dopaminergic deficiencies in neurological disorders.
Formula:C14H21NO
InChI:InChI=1/C14H21NO/c1-3-9-15-12-7-8-13-11(10-12)5-4-6-14(13)16-2/h4-6,12,15H,3,7-10H2,1-2H3/t12-/m0/s1
SMILES:CCCN[C@H]1CCc2c(cccc2OC)C1
Synonyms:
  • (2S)-5-Methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine
  • 2-naphthalenamine, 1,2,3,4-tetrahydro-5-methoxy-N-propyl-, (2S)-
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