CAS 101515-08-6: 7-deaza-2'-deoxyguanosine 5'-*triphosphate lithiu
Description:7-Deaza-2'-deoxyguanosine 5'-triphosphate lithium, often abbreviated as 7-deaza-dGTP, is a modified nucleotide that serves as a substrate in various biochemical applications, particularly in molecular biology and genetic research. This compound is characterized by the absence of a nitrogen atom at the 7-position of the guanine base, which alters its hydrogen bonding properties and enhances its stability during enzymatic reactions. The triphosphate group provides the necessary energy for incorporation into nucleic acid strands, making it useful in techniques such as PCR and DNA sequencing. The lithium salt form aids in solubility and stability in aqueous solutions. 7-deaza-dGTP is particularly valuable for studying nucleic acid interactions and for synthesizing modified oligonucleotides, as it can help reduce the formation of secondary structures and improve the fidelity of DNA synthesis. Overall, this compound is an important tool in the field of nucleic acid chemistry and molecular biology.
Formula:C11H17N4O13P3
InChI:InChI=1/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)/t6-,7+,8+/m0/s1
- Synonyms:
- 2'-Deoxy-7-deazaguanosine triphosphate
- 2'-Deoxy-7-deaza-GTP
- 7-Deaza-2'-deoxyguanosine triphosphate
- 7-Deaza-2'-dgtp
- C7-Gdtp
- 4H-Pyrrolo(2,3-d)pyrimidin-4-one, 2-amino-7-(2-deoxy-5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-erythro-pentofuranosyl)-1,7-dihydro-
- 2-amino-7-[2-deoxy-5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-beta-D-erythro-pentofuranosyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
