CAS 101515-08-6

7-deaza-2'-deoxyguanosine 5'-*triphosphate lithiu

Description:

7-Deaza-2'-deoxyguanosine 5'-triphosphate lithium, often abbreviated as 7-deaza-dGTP, is a modified nucleotide that serves as a substrate in various biochemical applications, particularly in molecular biology and genetic research. This compound is characterized by the absence of a nitrogen atom at the 7-position of the guanine base, which alters its hydrogen bonding properties and enhances its stability during enzymatic reactions. The triphosphate group provides the necessary energy for incorporation into nucleic acid strands, making it useful in techniques such as PCR and DNA sequencing. The lithium salt form aids in solubility and stability in aqueous solutions. 7-deaza-dGTP is particularly valuable for studying nucleic acid interactions and for synthesizing modified oligonucleotides, as it can help reduce the formation of secondary structures and improve the fidelity of DNA synthesis. Overall, this compound is an important tool in the field of nucleic acid chemistry and molecular biology.

Formula: C₁₁H₁₇N₄O₁₃P₃

InChI: InChI=1/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)/t6-,7+,8+/m0/s1

Synonyms:

• 2'-Deoxy-7-deazaguanosine triphosphate
• 2'-Deoxy-7-deaza-GTP
• 7-Deaza-2'-deoxyguanosine triphosphate
• 7-Deaza-2'-dgtp
• C7-Gdtp
• 4H-Pyrrolo(2,3-d)pyrimidin-4-one, 2-amino-7-(2-deoxy-5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-erythro-pentofuranosyl)-1,7-dihydro-
• 2-amino-7-[2-deoxy-5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-beta-D-erythro-pentofuranosyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt

CAS: 101515-08-6

Formula: C₁₁H₁₇N₄O₁₃P₃

Molecular weight: 506.19

Ref: 7W-GK7906

7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt - 100mM aqueous solution

CAS: 101515-08-6

7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt is a nucleoside analog that inhibits telomerase. It binds to the catalytic subunit of telomerase, which is an RNA-dependent DNA polymerase that synthesizes telomeres during DNA replication. This binding prevents the enzyme from extending the 3' end of the DNA strand, inhibiting cell proliferation and leading to apoptosis. Telomerase inhibition has been shown to have an inhibitory effect on insulin resistance in mice. 7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt also inhibits protein kinases, but does not inhibit phosphatases or other enzymes.

Formula: C₁₁H₁₇N₄O₁₃P₃·xLi

Purity: Min. 95%

Molecular weight: 506.19 g/mol

Ref: 3D-ND157323

7-Deaza-2′-deoxyguanosine 5′-triphosphate

CAS: 101515-08-6

7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].

Formula: C₁₁H₁₇N₄O₁₃P₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 506.19

Ref: TM-T83248

7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt - 10mM aqueous solution

CAS: 101515-08-6

7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt is a cytosolic small molecule that inhibits the activity of telomerase, an enzyme involved in the replication of chromosomes. It also has inhibitory effects on kinase domains and may be used to treat cancer. 7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt binds to human mitochondrial DNA and inhibits gene transcription by hybridizing with it. This results in the inhibition of dopamine production, which can be helpful for treating Parkinson's disease. 7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt is structurally similar to 2'-deoxyadenosine 5'-triphosphate (dATP) and can be incorporated into DNA by phosphorylation to form a covalent bond that disrupts the dATP/ATP ratio. This causes cellular energy production to decrease and

Formula: C₁₁H₁₇N₄O₁₃P₃·xNa

Purity: Min. 95%

Molecular weight: 506.19 g/mol

Ref: 3D-ND157324