CAS 101527-46-2: alpha,alpha-difluorothymidine

Description: Alpha,alpha-Difluorothymidine (DFT) is a synthetic nucleoside analog of thymidine, characterized by the presence of two fluorine atoms at the alpha position of the sugar moiety. This modification enhances its stability and alters its interaction with nucleic acid synthesis pathways. DFT is primarily studied for its potential antiviral and anticancer properties, as it can inhibit viral replication and interfere with DNA synthesis in rapidly dividing cells. The compound exhibits a polar nature due to the presence of fluorine, which can influence its solubility and permeability across biological membranes. Additionally, DFT's structural similarity to natural nucleosides allows it to be incorporated into DNA, potentially leading to chain termination during replication. Its mechanism of action and efficacy are subjects of ongoing research, particularly in the context of treating viral infections and certain types of cancer. As with many fluorinated compounds, careful consideration of its pharmacokinetics and toxicity is essential in therapeutic applications.

Formula: C₁₀H₁₂F₂N₂O₅

InChI: InChI=1/C10H12F2N2O5/c11-8(12)4-2-14(10(18)13-9(4)17)7-1-5(16)6(3-15)19-7/h2,5-8,15-16H,1,3H2,(H,13,17,18)/t5-,6+,7+/m0/s1

Synonyms:

• 5-Difluoromethyl-2'-deoxyuridine
• F2-Tdr
• Thymidine, alpha,alpha-difluoro-
• 2'-Deoxy-5-(Difluoromethyl)Uridine
• alpha,alpha-Difluorothymidine

Thymidine, α,α-difluoro- (9CI)

CAS: 101527-46-2

• Formula: C₁₀H₁₂F₂N₂O₅
• Molecular weight: 278.2095

α,α-Difluorothymidine

CAS: 101527-46-2

Alpha,alpha-Difluorothymidine is a fluorinated form of thymine and is used in the treatment of herpes …

• Formula: C₁₀H₁₂F₂N₂O₅
• Purity: Min. 95%
• Molecular weight: 278.21 g/mol