CAS 101554-76-1

.epsilon.-N-Maleimidocaproic acid-(2-nitro-4-sulfo)-phenyl ester . sodium salt

Description:

.epsilon.-N-Maleimidocaproic acid-(2-nitro-4-sulfo)-phenyl ester sodium salt, with CAS number 101554-76-1, is a chemical compound characterized by its maleimide functional group, which is known for its ability to form stable covalent bonds with thiol groups. This compound features a sulfonic acid group, enhancing its solubility in aqueous environments, making it suitable for various biochemical applications. The presence of the nitro group contributes to its reactivity and potential use in labeling or modifying biomolecules. Typically, this compound is utilized in bioconjugation processes, particularly in the development of targeted drug delivery systems and in the creation of biosensors. Its sodium salt form indicates that it is likely to be more soluble in water compared to its acid form, facilitating its use in biological systems. Overall, this compound is valuable in research and industrial applications where specific interactions with thiol-containing molecules are required.

Formula: C₁₆H₁₆N₂NaO₉S

InChI: InChI=1/C16H16N2O9S.Na/c19-14-7-8-15(20)17(14)9-3-1-2-4-16(21)27-13-6-5-11(28(24,25)26)10-12(13)18(22)23;/h5-8,10H,1-4,9H2,(H,24,25,26);/q;+1

SMILES: C(CCC(=O)Oc1ccc(cc1N(=O)=O)S(=O)(=O)O)CCN1C(=O)C=CC1=O.[Na]

Synonyms:

• N-Maleimido-6-aminocaproyl 1-hydroxy-2-nitro-4-benzenesulfonic acid ester
• Mal-sac-hnsa
• Benzenesulfonic acid, 4-((6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl)oxy)-3-nitro-, sodium salt
• 1H-pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-nitro-4-sulfophenyl ester, sodium salt (1:1)

Sodium 4-((6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)oxy)-3-nitrobenzenesulfonate

CAS: 101554-76-1

Formula: C₁₆H₁₅N₂NaO₉S

Molecular weight: 434.3531

Ref: IN-DA0004RQ

ε-Maleimidocaproic acid-(2-nitro-4-sulfo)-phenyl ester·sodium salt

CAS: 101554-76-1

Epsilon-Maleimidocaproic acid-(2-nitro-4-sulfo)-phenyl ester·sodium salt (EMAP) is a crosslinker that belongs to the group of heterobifunctional reagents. It has been used to conjugate monoclonal antibodies with other molecules, such as toxins. EMAP is activated by the dianion generated by protonation of the nitro groups on the phenyl ring and reacts with free amines or thiols in proteins. EMAP can be used for labeling immunotoxins for diagnostic use, maximizing detection sensitivity, and crosslinking DNA molecules for use in molecular cloning experiments.

Formula: C₁₆H₁₅N₂NaO₉S

Purity: Min. 95%

Molecular weight: 434.35 g/mol

Ref: 3D-FM111177

ε-Maleimidocaproic acid-(2-nitro-4-sulfo)-phenyl ester · sodium salt

CAS: 101554-76-1

mal-sac-HNSA, an often used freely water-soluble, heterobifunctional crosslinking reagent for conjugation of sulfhydryl (cysteine)-containing peptides to carrier proteins. The reaction of mal-sac-HNSA with amino groups can be monitored spectrophotometrically due to the concomitant release of the dianion of 1-hydroxy-2-nitro-4-benzenesulfonic acid.

Formula: C₁₆H₁₅N₂NaO₉S

Purity: 99.7%

Color and Shape: Whitish

Molecular weight: 434.36

Ref: 01-4013577