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CAS 10159-53-2

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Phosphoramide mustard

Description:
Phosphoramide mustard, with the CAS number 10159-53-2, is a synthetic chemical compound that belongs to the class of alkylating agents. It is characterized by its ability to form covalent bonds with nucleophilic sites in DNA, leading to cross-linking and subsequent disruption of DNA replication and transcription. This mechanism underlies its potential use in cancer chemotherapy, as it can selectively target rapidly dividing cells. The compound is a derivative of nitrogen mustard and contains a phosphoramide group, which enhances its stability and solubility compared to traditional nitrogen mustards. Phosphoramide mustard is typically administered in a controlled manner due to its cytotoxic effects, and its pharmacological profile includes both antitumor activity and potential side effects, such as myelosuppression and gastrointestinal toxicity. Safety precautions are essential when handling this compound, as it can pose risks to human health and the environment. Overall, phosphoramide mustard exemplifies the dual nature of chemotherapeutic agents, offering therapeutic benefits while necessitating careful management of their toxicological properties.
Formula:C4H11Cl2N2O2P
InChI:InChI=1S/C4H11Cl2N2O2P/c5-1-3-8(4-2-6)11(7,9)10/h1-4H2,(H3,7,9,10)
InChI key:InChIKey=RJXQSIKBGKVNRT-UHFFFAOYSA-N
SMILES:N(P(N)(=O)O)(CCCl)CCCl
Synonyms:
  • Asta 5317
  • Brn 1775144
  • Ccris 5127
  • Friedman acid
  • N,N-Bis(2-chloroethyl)phosphorodiamidic acid
  • N,N-Bis(chloroethyl)phosphorodiamidic acid
  • N-Lost-phosphorsaeurediamid
  • N-Lost-phosphorsaeurediamid [German]
  • Nlpd
  • Phosphamide mustard
  • See more synonyms
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