CAS 101803-03-6

N2-ETHYL-2'-DEOXYGUANOSINE

Description:

N2-Ethyl-2'-deoxyguanosine is a modified nucleoside that features an ethyl group attached to the nitrogen at the 2 position of the guanine base. This modification can influence the nucleoside's properties, including its stability, reactivity, and interaction with nucleic acids. The presence of the ethyl group may affect hydrogen bonding and base pairing, potentially altering the nucleoside's role in DNA synthesis and repair mechanisms. N2-Ethyl-2'-deoxyguanosine is of interest in biochemical research, particularly in studies related to mutagenesis and the effects of alkylating agents on DNA. Its structural modifications can also provide insights into the mechanisms of drug action and the development of therapeutic agents. The compound is typically analyzed using techniques such as chromatography and mass spectrometry to determine its purity and structural characteristics. As a synthetic analog of natural nucleosides, it serves as a valuable tool in molecular biology and medicinal chemistry.

Formula: C₁₂H₁₇N₅O₄

InChI: InChI=1/C12H17N5O4/c1-2-13-12-15-10-9(11(20)16-12)14-5-17(10)8-3-6(19)7(4-18)21-8/h5-8,18-19H,2-4H2,1H3,(H2,13,15,16,20)/t6-,7+,8+/m0/s1

Synonyms:

• 2'-deoxy-N-ethylguanosine
• guanosine, 2'-deoxy-N-ethyl-
• 2-ethylamino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one
• N2-ethyl-2'-deoxyguanosine

2'-Deoxy-N-ethylguanosine-d6

Controlled Product

CAS: 101803-03-6

Applications 2'-Deoxy-N-ethylguanosine-d6 is the isotope labelled analog of 2'-Deoxy-N-ethylguanosine (D232925), a acetaldehyde derived DNA adduct formed in human leukocyte DNA of healthy individuals following alcohol consumption.
References Singh, R., et al.: Mutat. Res. Funda. Molec. Mechan. Mutagen., 737, 8 (2012); Balbo, S., et al.: Cancer. Epidemiol. Biomarkers. Prevent., 21, 601 (2012);

Formula: C₁₂H₁₁D₆N₅O₄

Color and Shape: White To Off-White

Molecular weight: 301.33

Ref: TR-D232928

2'-Deoxy-N-ethylguanosine

Controlled Product

CAS: 101803-03-6

Applications 2'-Deoxy-N-ethylguanosine is an acetaldehyde derived DNA adduct formed in human leukocyte DNA of healthy individuals following alcohol consumption.
References Singh, R., et al.: Mutat. Res. Funda. Molec. Mechan. Mutagen., 737, 8 (2012); Balbo, S., et al.: Cancer. Epidemiol. Biomarkers. Prevent., 21, 601 (2012);

Formula: C₁₂H₁₇N₅O₄

Color and Shape: Neat

Molecular weight: 295.2945

Ref: TR-D232925

N2-Ethyl-2′-deoxyguanosine - 98 % HPLC

CAS: 101803-03-6

N2-Ethyl-2′-deoxyguanosine is an important metabolite of N2-ethyl-3′,5′-dideoxyadenosine (NEDA) and has been detected in urine samples from Sprague-Dawley rats. The biological properties of this metabolite are not well understood, but it has been shown to have genotoxic effects in mammalian cells and to be carcinogenic in a rat model. N2-Ethyl-2′-deoxyguanosine is also able to enhance the repair of damaged DNA and has functional groups that are similar to those found in cancer cells.

Formula: C₁₂H₁₇N₅O₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 295.29 g/mol

Ref: 3D-NE179476