CAS 101828-21-1

Butenafine

Description:

Butenafine is an antifungal agent primarily used in the treatment of dermatophyte infections, such as athlete's foot and ringworm. It belongs to the class of compounds known as benzylamines and functions by inhibiting the enzyme squalene epoxidase, which is crucial in the biosynthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to the accumulation of toxic squalene and ultimately results in fungal cell death. Butenafine is typically available in topical formulations, allowing for localized treatment with minimal systemic absorption. Its chemical structure features a butenyl group, contributing to its efficacy and specificity against various fungal pathogens. The substance is generally well-tolerated, with a low incidence of side effects, making it a preferred choice for treating superficial fungal infections. As with any medication, it is important to follow usage guidelines and consult healthcare professionals for appropriate application and potential interactions.

Formula: C₂₃H₂₇N

InChI: InChI=1/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3

InChI key: InChIKey=ABJKWBDEJIDSJZ-UHFFFAOYSA-N

SMILES: C(N(CC1=CC=C(C(C)(C)C)C=C1)C)C=2C3=C(C=CC2)C=CC=C3

Synonyms:

• 1-(4-tert-Butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
• 1-Naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-
• N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine
• N-[[4-(1,1-Dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine
• Butenafine
• N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine
• 4-tert-Butylbenzylmethyl 1-naphtylmethylamine
• N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine
• n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine

1-Naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-

CAS: 101828-21-1

Formula: C₂₃H₂₇N

Purity: 98%

Color and Shape: Solid

Molecular weight: 317.4672

Ref: IN-DA0005NN

Butenafine

CAS: 101828-21-1

Formula: C₂₃H₂₇N

Molecular weight: 317.47

Ref: 7W-GP4927

Butenafine

CAS: 101828-21-1

Butenafine hydrochloride is a mycological agent that is used to treat tinea. It has been shown to have an antifungal activity in vitro against wild-type strains of c. glabrata. Butenafine hydrochloride inhibits the synthesis of ergosterol, which is a vital component of fungal cell membranes, by blocking the conversion of squalene to lanosterol through inhibition of 14alpha-demethylase. It also has antimicrobial properties, which may be due to its ability to inhibit bacterial growth.

Formula: C₂₃H₂₇N

Purity: Min. 95%

Molecular weight: 317.47 g/mol

Ref: 3D-FB71433

Butenafine

CAS: 101828-21-1

Butenafine hydrochloride, a squalene epoxidase inhibitor, disrupts ergosterol synthesis, increasing cell membrane permeability.

Formula: C₂₃H₂₇N

Purity: 98%

Color and Shape: Solid

Molecular weight: 317.47

Ref: TM-T21365

Butenafine

Controlled Product

CAS: 101828-21-1

Formula: C₂₃H₂₇N

Color and Shape: Neat

Molecular weight: 317.467

Ref: TR-B690338