CAS 1018450-26-4: Fosdevirine

Description:Fosdevirine is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs), which function by inhibiting the reverse transcriptase enzyme, thereby preventing the replication of the virus. The chemical structure of fosdevirine features a unique bicyclic core that contributes to its activity and selectivity against HIV. It is characterized by its moderate lipophilicity, which influences its absorption and distribution in the body. Fosdevirine has shown a favorable pharmacokinetic profile, with a relatively long half-life, allowing for once-daily dosing. Additionally, it has demonstrated efficacy against various HIV strains, including those resistant to other NNRTIs. Safety and tolerability profiles are generally acceptable, with common side effects including gastrointestinal disturbances and skin rashes. As an investigational drug, fosdevirine represents a promising option in the ongoing effort to improve HIV treatment regimens and address drug resistance.

Formula:C₂₀H₁₇ClN₃O₃P

InChI:InChI=1S/C20H17ClN3O3P/c1-12-8-13(4-3-7-22)10-15(9-12)28(26,27-2)19-16-11-14(21)5-6-17(16)24-18(19)20(23)25/h3-6,8-11,24H,1-2H3,(H2,23,25)/b4-3+/t28-/m1/s1

InChI key:InChIKey=CGBYTKOSZYQOPV-ASSBYYIWSA-N

SMILES:N#CC=CC=1C=C(C=C(C1)P(=O)(OC)C=2C=3C=C(Cl)C=CC3NC2C(=O)N)C

Synonyms:
Fosdevirine
1DX899
Phosphinic acid, P-[2-(aminocarbonyl)-5-chloro-1H-indol-3-yl]-P-[3-[(1E)-2-cyanoethenyl]-5-methylphenyl]-, methyl ester, [P(R)]-
IDX 899
GSK 2248761A