CAS 10199-89-0

NBD-Cl

Description:

NBD-Cl, or 7-chloro-4-nitrobenzofurazan, is a chemical compound characterized by its bright yellow color and high reactivity, particularly towards nucleophiles. It features a benzofurazan ring structure, which contributes to its unique optical properties, making it useful in various applications, including fluorescence labeling and as a reagent in organic synthesis. The presence of the nitro and chloro substituents enhances its electrophilic character, allowing it to participate in nucleophilic substitution reactions. NBD-Cl is often employed in the development of fluorescent probes and in the study of biological systems due to its ability to form stable conjugates with amines and thiols. Additionally, it is sensitive to light and moisture, necessitating careful handling and storage conditions to maintain its stability. Overall, NBD-Cl is a valuable tool in chemical research and analytical chemistry, particularly in the fields of biochemistry and molecular biology.

Formula: C₆H₂ClN₃O₃

InChI: InChI=1S/C6H2ClN3O3/c7-3-1-2-4(10(11)12)6-5(3)8-13-9-6/h1-2H

InChI key: InChIKey=IGHBXJSNZCFXNK-UHFFFAOYSA-N

SMILES: N(=O)(=O)C=1C=2C(C(Cl)=CC1)=NON2

Synonyms:

• 2,1,3-Benzoxadiazole, 4-chloro-7-nitro-
• 4-Chloro-7-Nitro-2,1,3-Benzoxadiazole
• 4-Chloro-7-Nitrobenzo[C][1,2,5]Oxadiazole
• 4-Chloro-7-nitro-2,1,3-benzooxadiazole
• 4-Chloro-7-nitrobenz-2-oxa-1,3-diazole
• 4-Chloro-7-nitrobenz-2-oxa-1,3-diazole (NBD chloride
• 4-Chloro-7-nitrobenzo-2,1,3-oxadiazole~NBD chloride
• 4-Chloro-7-nitrobenzofurazan)
• 4-Chloro-7-nitrobezofurazan
• 7-Chloro-4-nitro-2,1,3-benzoxadiazole
• 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole
• 7-Chloro-4-nitrobenzofurazan
• 7-Nitro-4-chlorobenzofurazan
• 7-Nitrobenzo-2-oxa-1,3-diazol-4-yl chloride
• Benzofurazan, 4-chloro-7-nitro-
• NBD-Cl

NBD-Cl (=4-Chloro-7-nitro-2,1,3-benzoxadiazole) [for HPLC Labeling]

CAS: 10199-89-0

Formula: C₆H₂ClN₃O₃

Purity: >98.0%(T)

Color and Shape: Light yellow to Yellow powder to crystal

Molecular weight: 199.55

Ref: 3B-A5592

4-Chloro-7-nitrobenzofurazan, 98%

CAS: 10199-89-0

4-Chloro-7-nitrobenzofurazan is used as a derivatizing reagent for chromatography analysis of amino acids and low molecular weight amines. It is utilized in the preparation of fluorescent phospholipid-derivative, hydroxynaphthofurazan and 4-chloro-7-nitrobenzofurazan- didecanoylphosphatidylethanolam

Formula: C₆H₂ClN₃O₃

Purity: 98%

Color and Shape: Crystals or powder or crystalline powder, Yellow to pale brown

Molecular weight: 199.55

Ref: 02-A14165

2,1,3-Benzoxadiazole, 4-chloro-7-nitro-

CAS: 10199-89-0

Formula: C₆H₂ClN₃O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 199.5514

Ref: IN-DA00066P

NBD-Cl

CAS: 10199-89-0

NBD-Cl

Purity: ≥98%

Molecular weight: 199.55g/mol

Ref: 54-BUP18438

4-Chloro-7-nitro-2,1,3-benzoxadiazole

CAS: 10199-89-0

4-Chloro-7-nitro-2,1,3-benzoxadiazole

Formula: C₆H₂ClN₃O₃

Purity: 98%

Color and Shape: yellow powder

Molecular weight: 199.55g/mol

Ref: 54-OR25548

NBD-Cl

CAS: 10199-89-0

Formula: C₆H₂ClN₃O₃

Purity: ≥ 97.0%

Color and Shape: Yellow powder

Molecular weight: 199.55

Ref: 7W-GW4810

NBD-Cl

CAS: 10199-89-0

NBD-Cl (NBD chloride) is a nonfluorescent compound that becomes highly fluorescent after reaction with amino or thiol groups.

Formula: C₆H₂ClN₃O₃

Purity: 99.61% - 99.99%

Color and Shape: Yellow To Light Brown Crystalline Powder

Molecular weight: 199.55

Ref: TM-T19030

4-Chloro-7-nitro-2,1,3-benzoxadiazole

Controlled Product

CAS: 10199-89-0

Applications A fluorescent reagent used to evaluate peptides, pharmaceutical drugs and other bioactive compounds.
References Rudat, B. et al.: Eur. J. Med. Chem., 46, 4457 (2011); Michail, K. et al.: Int. J. Pharm. Pharmac. Sci., 3, 180 (2011); Walsh, M. et al.: J. Fluoresc., 21, 105 (2011);

Formula: C₆H₂ClN₃O₃

Color and Shape: Yellow

Molecular weight: 199.55

Ref: TR-C373895

4-Chloro-7-nitrobenzofurazan

CAS: 10199-89-0

4-Chloro-7-nitrobenzofurazan is a fluorescent derivative that binds to the α subunit of DNA polymerase. It can be used as an analytical method for the detection of DNA polymerase inhibitors. 4-Chloro-7-nitrobenzofurazan has also been shown to inhibit cell nuclei and human serum, as well as binding to reactive sites on human cells. This compound can be used in control analysis for laboratory experiments related to protein synthesis and cell death.

Formula: C₆H₂ClN₃O₃

Purity: Min. 97 Area-%

Color and Shape: Yellow Powder

Molecular weight: 199.55 g/mol

Ref: 3D-FC01109

4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole

CAS: 10199-89-0

Formula: C₆H₂ClN₃O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 199.55

Ref: 10-F221943