(Ile7)-angiotensin III acetate, identified by the CAS number 102029-49-2, is a synthetic peptide that is a derivative of angiotensin III, a biologically active peptide involved in the regulation of blood pressure and fluid balance. This compound features a modified amino acid sequence, specifically incorporating isoleucine at the seventh position, which enhances its biological activity and stability compared to its natural counterparts. The acetate form indicates that the peptide is acetylated, which can influence its solubility and pharmacokinetic properties. Characteristically, (Ile7)-angiotensin III acetate exhibits properties such as high affinity for angiotensin receptors, particularly the AT1 receptor, and plays a role in vasoconstriction and aldosterone secretion. Its potential applications include research in cardiovascular physiology and the development of therapeutic agents targeting the renin-angiotensin system. As with many peptides, its stability, solubility, and bioactivity can be influenced by factors such as pH, temperature, and the presence of other ions or molecules in the environment.

(ile7)-angiotensin iii acetate

102029-49-2: (Ile7)-angiotensin III acetate, identified by the CAS number 102029-49-2, is a synthetic peptide that is a derivative of angiotensin III, a biologically active peptide involved in the regulation of blood pressure and fluid balance. This compound features a modified amino acid sequence, specifically incorporating isoleucine at the seventh position, which enhances its biological activity and stability compared to its natural counterparts. The acetate form indicates that the peptide is acetylated, which can influence its solubility and pharmacokinetic properties. Characteristically, (Ile7)-angiotensin III acetate exhibits properties such as high affinity for angiotensin receptors, particularly the AT1 receptor, and plays a role in vasoconstriction and aldosterone secretion. Its potential applications include research in cardiovascular physiology and the development of therapeutic agents targeting the renin-angiotensin system. As with many peptides, its stability, solubility, and bioactivity can be influenced by factors such as pH, temperature, and the presence of other ions or molecules in the environment.

<p>Des-Asp1-[Ile8]-Angiotensin II is a peptide that has been shown to have analgesic effects. It has been reported to be active in anesthetized, Sprague-Dawley rats and in primary cultures of rat brain neurons. The peptide binds to the angiotensin II type 1 receptor (AT1) subtype and enhances the activity of the receptor when it is bound by angiotensin II. Des-Asp1-[Ile8]-Angiotensin II also inhibits aminopeptidase activity, leading to an increase in the concentration of angiotensin II. This leads to increased antinociception at high concentrations, which may be due to its effect on baroreceptors or mesenteric blood vessels.</p>

CAS 102029-49-2

(ile7)-angiotensin iii acetate

Des-Asp1-[Ile8]-Angiotensin II

Ref: 3D-PAN-4037