CAS 102029-89-0

(sar1)-angiotensin ii acetate

Description:

(Sar1)-angiotensin II acetate is a synthetic analog of the naturally occurring peptide hormone angiotensin II, which plays a crucial role in regulating blood pressure and fluid balance. This compound is characterized by its specific amino acid substitution at the first position, where sarcosine (Sar) replaces the natural amino acid, leading to altered biological activity and receptor binding properties. The acetate form indicates that the compound is acetylated, which can enhance its stability and solubility. (Sar1)-angiotensin II acetate is typically utilized in research settings to study the angiotensin system, particularly in relation to cardiovascular physiology and pathophysiology. Its structural modifications allow for the exploration of receptor interactions and the development of potential therapeutic agents targeting hypertension and related disorders. As with many peptide analogs, it may exhibit differences in potency and efficacy compared to the native angiotensin II, making it a valuable tool in pharmacological studies.

Formula: C₄₉H₇₁N₁₃O₁₀

Synonyms:

• Sar-Arg-Val-Tyr-Ile-His-Pro-Phe

[Sar1]-Angiotensin II

Controlled Product

CAS: 102029-89-0

Angiotensin II is a peptide hormone that is secreted by the kidneys. It stimulates the release of aldosterone and causes vasoconstriction, leading to an increase in blood pressure. Angiotensin II is also involved in other physiological functions such as the regulation of fluid balance, electrolyte levels, and blood coagulation. The drug is used to treat congestive heart failure and high blood pressure. Sar1-Angiotensin II has been shown to inhibit transcriptional regulation by binding to the angiotensin receptor type 1 (AT1). This binding disrupts conformational changes in the receptor, preventing signal transduction from occurring and decreasing the activity of enzymes such as protein kinase A, which are needed for activation of transcription factors.

Formula: C₄₉H₇₁N₁₃O₁₀•(C₂H₄O₂)₂

Purity: Min. 95%

Molecular weight: 1,122.28 g/mol

Ref: 3D-PAN-3948-PI