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CAS 102042-09-1

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21-hydroxyoligomycin A

Description:
21-Hydroxyoligomycin A is a naturally occurring macrolide antibiotic that is derived from the fermentation of certain Streptomyces species. It is characterized by its complex structure, which includes a large lactone ring and multiple hydroxyl groups, contributing to its biological activity. This compound is known for its ability to inhibit ATP synthase, an essential enzyme in the mitochondrial respiratory chain, thereby affecting cellular energy production. The inhibition of ATP synthase can lead to a decrease in ATP levels, which has implications for various cellular processes. Additionally, 21-hydroxyoligomycin A exhibits antifungal and antibacterial properties, making it of interest in pharmaceutical research. Its solubility and stability can vary depending on the solvent and conditions, which is important for its application in biological studies. As with many macrolides, it may also exhibit side effects and interactions with other drugs, necessitating careful consideration in therapeutic contexts. Overall, 21-hydroxyoligomycin A represents a significant compound in the study of bioenergetics and antimicrobial activity.
Formula:C45H74O12
InChI:InChI=1/C45H74O12/c1-12-33-17-15-13-14-16-27(4)43(10,53)44(11,54)42(52)31(8)41(51)30(7)40(50)29(6)39(49)26(3)18-19-38(48)55-37-24-34(23-35(33)47)56-45(32(37)9)21-20-25(2)36(57-45)22-28(5)46/h13-15,17-19,25-37,39,41,46-47,49,51,53-54H,12,16,20-24H2,1-11H3/b14-13-,17-15+,19-18+/t25-,26+,27+,28+,29+,30-,31-,32-,33-,34?,35?,36-,37?,39+,41+,43-,44-,45?/m0/s1
Synonyms:
  • 21-Hydroxyl-oligomycin A
  • Oligomycin A, 21-hydroxy-
  • (5'S,6R,6'S,7R,8R,10R,11R,12S,14R,15S,16R,22S,28S)-22-ethyl-7,11,14,15,23-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,15,16,28-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione (non-preferred name)
  • 21-Hydroxyoligomycin A
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