CAS 102052-95-9

3-Deazaneplanocin

Description:

3-Deazaneplanocin, with the CAS number 102052-95-9, is a synthetic compound that belongs to the class of nucleoside analogs. It is characterized by its unique bicyclic structure, which includes a seven-membered ring containing nitrogen atoms. This compound is known for its potent antiviral and anticancer properties, particularly in the context of inhibiting the replication of certain viruses and the growth of cancer cells. 3-Deazaneplanocin functions as an inhibitor of S-adenosylhomocysteine hydrolase, an enzyme involved in the metabolism of adenosine, which plays a crucial role in various biological processes. Its mechanism of action involves the disruption of cellular methylation processes, leading to altered gene expression and cellular function. Due to its biological activity, 3-Deazaneplanocin has been the subject of research in the fields of virology and oncology, although its clinical use may be limited by factors such as toxicity and bioavailability. Overall, this compound represents a significant area of interest for therapeutic development in treating viral infections and cancer.

Formula: C₁₂H₁₄N₄O₃

InChI: InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1

InChI key: InChIKey=OMKHWTRUYNAGFG-IEBDPFPHSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CC3)C=C(CO)[C@H]1O

Synonyms:

• (1R,4R,5S)-4-(5-amino-4,7,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraen-9-yl)-2-(hydroxymethyl)cyclopent-2-ene-1,5-diol
• (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol
• (1S,2R,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
• 1H-Imidazo[4,5-c]pyridine, 3-cyclopentene-1,2-diol deriv.
• 3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-
• 3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, [1S-(1α,2α,5β)]-
• 3-Deazaneplanocin A
• DZNeP
• NSC 617989

3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-

CAS: 102052-95-9

Formula: C₁₂H₁₄N₄O₃

Purity: %

Color and Shape: Solid

Molecular weight: 262.2646

Ref: IN-DA0006H5

(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol

CAS: 102052-95-9

(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol

Purity: 98%

Molecular weight: 262.27g/mol

Ref: 54-OR1074650

3-Deazaneplanocin hydrochloride - Technical

CAS: 102052-95-9

Inhibitor of S-adenosylhomocysteine hydrolase that disrupts histone methylation by EZH2. Anti-proliferative in some breast cancer and invasive prostate cancer cell lines. One of four key molecules required for inducing chemical reprogramming of somatic cells into induced pluripotent stem cells (iPSC).

Formula: C₁₂H₁₄N₄O₃·ClH

Purity: Min. 70 Area-%

Color and Shape: Powder

Molecular weight: 298.73 g/mol

Ref: 3D-FD64921

3-Deazaneplanocin A

CAS: 102052-95-9

3-Deazaneplanocin A (DZNep) is an EZH2 and AHCY inhibitor with antipoxigenic activity that inhibits fibrosis in the liver, kidneys, peritoneum, and airways.

Formula: C₁₂H₁₄N₄O₃

Purity: 99.03% - 99.68%

Color and Shape: Solid

Molecular weight: 262.27

Ref: TM-T6292