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CAS 10212-19-8

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2'-Chloro-2'-deoxycytidine

Description:
2'-Chloro-2'-deoxycytidine, commonly referred to as cladribine, is a synthetic nucleoside analog of deoxycytidine. It features a chlorine atom at the 2' position of the ribose sugar, which distinguishes it from natural nucleosides. This modification enhances its stability and alters its biological activity. Cladribine is primarily used in the treatment of certain hematological malignancies, such as hairy cell leukemia and multiple sclerosis, due to its ability to interfere with DNA synthesis and repair. The compound exhibits antimetabolite properties, leading to the inhibition of cell proliferation, particularly in rapidly dividing cells. In terms of solubility, cladribine is typically soluble in water and exhibits moderate stability under physiological conditions. Its mechanism of action involves incorporation into DNA, resulting in the disruption of normal cellular processes. As a pharmaceutical agent, cladribine is administered via injection, and its pharmacokinetics and dosing regimens are carefully managed to optimize therapeutic outcomes while minimizing potential side effects.
Formula:C9H12ClN3O4
InChI:InChI=1/C9H12ClN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6?,7-,8-/m1/s1
Synonyms:
  • 2'-Deoxy-2'-Chlorocytidine
  • 2'-CHLORO-2'-DEOXYCYTIDINE
  • -Chloro-2&rsquo
  • Cytidine, 2'-chloro-2'-deoxy- (8CI,9CI)
  • -deoxycytidine
  • 2-CHLORO-2'-DEOXYCYTIDINE
  • 4-Amino-1-((2R,3R,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
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