CAS 10212-25-6

Ancitabine hydrochloride

Description:

Ancitabine hydrochloride, also known as 1-β-D-arabinofuranosylcytosine hydrochloride, is a synthetic nucleoside analog of cytidine. It is primarily used in the treatment of certain types of cancer, particularly hematological malignancies. The substance exhibits antimetabolite properties, interfering with DNA synthesis and repair by mimicking the natural nucleoside, thereby inhibiting the proliferation of rapidly dividing cells. Ancitabine hydrochloride is typically administered via injection and is known for its ability to penetrate cellular membranes effectively. Its mechanism of action involves incorporation into DNA, leading to chain termination during replication. The compound is characterized by its solubility in water, which facilitates its use in clinical settings. However, like many chemotherapeutic agents, it can have significant side effects, including myelosuppression, gastrointestinal disturbances, and potential neurotoxicity. Monitoring and supportive care are essential during treatment to manage these adverse effects. Overall, Ancitabine hydrochloride plays a crucial role in oncology, particularly in combination therapies for enhancing treatment efficacy.

Formula: C₉H₁₁N₃O₄·ClH

InChI: InChI=1S/C9H11N3O4.ClH/c10-5-1-2-12-8-7(16-9(12)11-5)6(14)4(3-13)15-8;/h1-2,4,6-8,10,13-14H,3H2;1H/t4-,6-,7+,8-;/m1./s1

InChI key: InChIKey=KZOWNALBTMILAP-JBMRGDGGSA-N

SMILES: O[C@H]1[C@]2([C@](N3C(O2)=NC(=N)C=C3)(O[C@@H]1CO)[H])[H].Cl

Synonyms:

• (2R,3R,3aS,6E,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol
• (6E)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol
• 2,2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride
• 2,2'-Anhydro-cytidine Hydrochloride
• 2,2'-O-Cyclocytidine Hydrochloride
• 2,2'-dihydro-1-beta-D-arabinofuranosylcytosine hydrochloride
• 2,2′-Anhydro-1-β-<span class="text-smallcaps">D</span>-arabinofuranosylcytosine hydrochloride
• 2,2′-Anhydro-1-β-<span class="text-smallcaps">D</span>-arabinofuranosylcytosine monohydrochloride
• 2,2′-Anhydroarabinosylcytosine hydrochloride
• 2,2′-Anhydroaracytidine hydrochloride
• 2,2′-Anhydrocytidine hydrochloride
• 2,2′-Cyclocytidine hydrochloride
• 2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol
• 6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, hydrochloride
• 6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, hydrochloride (1:1), (2R,3R,3aS,9aR)-
• 6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, monohydrochloride, (2R,3R,3aS,9aR)-
• 6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, monohydrochloride, [2R-(2α,3β,3aβ,9aβ)]-
• 6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, monohydrochloride, stereoisomer
• Ancitabine hydrochloride
• Cyclo-CMP hydrochloride
• NSC 145668
• O²,O^2′-Anhydro-1-β-<span class="text-smallcaps">D</span>-arabinofuranosylcytosine monohydrochloride
• O²,O^2′-Anhydro-1-β-arabinofuranosylcytosine hydrochloride

Ancitabine Hydrochloride

CAS: 10212-25-6

Formula: C₉H₁₁N₃O₄·HCl

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 261.66

Ref: 3B-C2207

Cyclocytidine hydrochloride, 98+%

CAS: 10212-25-6

Anti-tumor agent

Formula: C₉H₁₁N₃O₄•HCl

Purity: 98+%

Molecular weight: 261.66

Ref: 02-J63845

(-)-Cyclocytidine hydrochloride

CAS: 10212-25-6

Formula: C₉H₁₂ClN₃O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 261.6623

Ref: IN-DA00H9R2

Ancitabine hydrochloride

CAS: 10212-25-6

Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.

Formula: C₉H₁₂ClN₃O₄

Purity: 99.02% - 99.37%

Color and Shape: White Solid

Molecular weight: 261.66

Ref: TM-T1591

Cytarabine EP Impurity H HCl (Ancitabine HCl, Cyclocytidine HCl)

CAS: 10212-25-6

Formula: C₉H₁₁N₃O₄·HCl

Molecular weight: 225.21 36.46

Ref: 4Z-C-150031

Ancitabine hydrochloride

CAS: 10212-25-6

Ancitabine hydrochloride

Purity: 98%

Molecular weight: 261.66g/mol

Ref: 54-OR1029075

Ancitabine hydrochloride

CAS: 10212-25-6

Ancitabine hydrochloride

Purity: ≥98%

Molecular weight: 261.66g/mol

Ref: 54-BUP16729

Ancitabine hydrochloride (Cyclocytidine hydrochloride)

CAS: 10212-25-6

Formula: C₉H₁₁N₃O₄HCl

Molecular weight: 261.66

Ref: 7W-GP5207

Ancitabine Hydrochloride

Controlled Product

CAS: 10212-25-6

Applications Ancitabine Hydrochloride is an antineoplastic agent.
References Ototani, N., Whistler, R.: J. Med. Chem., 17, 535 (1974); Smith, K., et al.: EMBO Mol. Med., 2, 371 (2010);

Formula: C₉H₁₁N₃O₄·HCl

Color and Shape: Neat

Molecular weight: 261.66

Ref: TR-A637288

2,2'-Anhydrocytidine HCl

CAS: 10212-25-6

2,2'-Anhydrocytidine HCl is a nucleoside for use as a DNA synthesis inhibitor

Formula: C₉H₁₁N₃O₄·HCl

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 261.66 g/mol

Ref: 3D-NA01967

Cyclocytidine hydrochloride

CAS: 10212-25-6

Formula: C₉H₁₂ClN₃O₄

Purity: 97%

Color and Shape: No data available.

Molecular weight: 261.66

Ref: 10-F463451