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CAS 102212-99-7

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5-bromo-2'-deoxyuridine 5'-triphosphate sodium

Description:
5-Bromo-2'-deoxyuridine 5'-triphosphate sodium (dBrUTP) is a nucleotide analog that incorporates a bromine atom at the 5-position of the uracil base. This compound is primarily used in molecular biology and biochemistry as a substrate for DNA polymerases during DNA synthesis and labeling experiments. Its structure includes a deoxyribose sugar, a triphosphate group, and the brominated uracil base, which allows it to participate in DNA replication and transcription processes. The presence of the bromine atom can affect the base-pairing properties and stability of the resulting DNA, making it useful for various applications, including the study of DNA dynamics and the development of antiviral therapies. As a sodium salt, it is typically soluble in aqueous solutions, facilitating its use in laboratory settings. Additionally, dBrUTP can be incorporated into DNA strands, allowing researchers to track and visualize DNA synthesis and repair mechanisms. Its unique properties make it a valuable tool in genetic research and therapeutic development.
Formula:C9H14BrN2NaO14P3
InChI:InChI=1/C9H14BrN2O14P3.Na/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18;/h2,5-7,13H,1,3H2,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18);
SMILES:C1C(C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)OC1n1cc(c(nc1=O)O)Br)O.[Na]
Synonyms:
  • 5-Bromo-2-deoxy-uridine-5-(tetrahydrogen triphosphate), tetrasodium salt
  • 2,4(1H,3H)-pyrimidinedione, 5-bromo-1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]pentofuranosyl]-, monosodium salt
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