CAS 1022150-12-4

3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyrimidin-4-amine

Description:

3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyrimidin-4-amine, with the CAS number 1022150-12-4, is a synthetic organic compound that belongs to the class of pyrazolopyrimidines. This compound features a pyrazolo[3,4-d]pyrimidine core, which is characterized by a fused bicyclic structure that includes both pyrazole and pyrimidine rings. The presence of a phenoxyphenyl group and a piperidyl substituent contributes to its potential biological activity, making it of interest in medicinal chemistry. The compound may exhibit properties such as enzyme inhibition or receptor modulation, which are common in drug candidates. Its molecular structure suggests potential interactions with various biological targets, possibly influencing pathways related to cell signaling or metabolic processes. Additionally, the compound's solubility, stability, and reactivity would be influenced by its functional groups, which are critical for its pharmacokinetic and pharmacodynamic profiles. Further studies would be necessary to elucidate its specific biological effects and therapeutic potential.

InChI: InChI=1S/C22H22N6O/c23-21-19-20(15-8-10-18(11-9-15)29-17-6-2-1-3-7-17)27-28(22(19)26-14-25-21)16-5-4-12-24-13-16/h1-3,6-11,14,16,24H,4-5,12-13H2,(H2,23,25,26)

SMILES: c1ccc(cc1)Oc1ccc(cc1)c1c2c(N)ncnc2n(C2CCCNC2)n1

Synonyms:

• 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
• (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-

CAS: 1022150-12-4

Formula: C₂₂H₂₂N₆O

Purity: 97%

Color and Shape: Solid

Molecular weight: 386.4497

Ref: IN-DA0006YL

IBT6A

CAS: 1022150-12-4

IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.

Formula: C₂₂H₂₂N₆O

Purity: 99.8% - 99.88%

Color and Shape: Solid

Molecular weight: 386.45

Ref: TM-T10625

IBT6A

CAS: 1022150-12-4

IBT6A

Purity: ≥98%

Molecular weight: 386.45g/mol

Ref: 54-BUP16561

3-(4-Phenoxy-Phenyl)-1-Piperidin-3-Yl-1H-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine

CAS: 1022150-12-4

3-(4-Phenoxy-Phenyl)-1-Piperidin-3-Yl-1H-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine

Purity: 99%

Molecular weight: 386.45g/mol

Ref: 54-OR1024705

Ibrutinib Impurity 18

CAS: 1022150-12-4

Formula: C₂₂H₂₂N₆O

Molecular weight: 386.46

Ref: 4Z-I-061023

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS: 1022150-12-4

Color and Shape: Neat

Ref: 86-MM3746.06

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS: 1022150-12-4

Applications (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an intermediate used to prepare pyrazolo-pyrimidine compounds as inhibitors of Bruton's tyrosine kinase. It is also an intermediate for Ibrutinib (I124970) derivatives.
References Chen, W., et al.: PCT Int. Appl. (2011), WO 2011046964 A2 20110421

Formula: C₂₂H₂₂N₆O

Color and Shape: White To Light Yellow

Molecular weight: 386.45

Ref: TR-P318770

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS: 1022150-12-4

Formula: C₂₂H₂₂N₆O

Purity: 97%

Color and Shape: Solid

Molecular weight: 386.459

Ref: 10-F424131

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-d4

Controlled Product

CAS: 1022150-12-4

Applications (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Formula: C₂₂D₄H₁₈N₆O

Color and Shape: Neat

Molecular weight: 390.47

Ref: TR-P318772