CAS 10226-54-7

3,7-Dihydro-1,3-dimethyl-7-(5-oxohexyl)-1H-purine-2,6-dione

Description:

3,7-Dihydro-1,3-dimethyl-7-(5-oxohexyl)-1H-purine-2,6-dione, with the CAS number 10226-54-7, is a purine derivative characterized by its complex structure, which includes a purine ring system and various substituents. This compound features two methyl groups at the 1 and 3 positions of the purine ring, contributing to its hydrophobic properties. The presence of a 5-oxohexyl side chain at the 7 position enhances its molecular diversity and may influence its biological activity. As a purine analog, it may interact with biological systems, potentially affecting nucleic acid metabolism or serving as a precursor in biochemical pathways. The compound is likely to exhibit solubility in organic solvents, with limited solubility in water due to its hydrophobic characteristics. Its potential applications could span pharmaceuticals, biochemistry, and molecular biology, particularly in studies related to nucleotides or as a research tool in understanding purine metabolism. However, specific biological activities and toxicity profiles would require further investigation through empirical studies.

Formula: C₁₃H₁₈N₄O₃

InChI: InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-8-14-11-10(17)12(19)16(3)13(20)15(11)2/h8H,4-7H2,1-3H3

InChI key: InChIKey=XBEDAMVJWVPVDS-UHFFFAOYSA-N

SMILES: C(CCCC(C)=O)N1C2=C(N(C)C(=O)N(C)C2=O)N=C1

Synonyms:

• 1,2,3,6-Tetrahydro-1,3-dimethyl-7-(5-oxohexyl)purin-2,6-dion
• 1,3-Dimethyl-7-(5-oxohexyl)-1H-purine-2,6(3H,7H)-dione
• 1,3-Dimethyl-7-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• 1,3-Dimethyl-7-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
• 1,3-Dimethyl-7-(5-oxohexyl)xanthine
• 10226-54-7
• 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(5-oxohexyl)-
• 233-547-0
• 3,7-Dihydro-1,3-dimethyl-7-(5-oxohexyl)-1H-purine-2,6-dione
• 7-(5-Oxohexyl)-1,3-dimethylxanthine
• Cervilane
• Lomifylline [INN]
• Purin-2,6-dione, 1,2,3,6-tetrahydro-1,3-dimethyl-7-(5-oxohexyl)-

1,3-Dimethyl-7-(5-oxohexyl)-1H-purine-2,6(3H,7H)-dione

CAS: 10226-54-7

Formula: C₁₃H₁₈N₄O₃

Color and Shape: Solid

Molecular weight: 278.3070

Ref: IN-DA00072F

Lomifylline

CAS: 10226-54-7

Formula: C₁₃H₁₈N₄O₃

Molecular weight: 278.31

Ref: 7W-GP0502

Lomifylline

Controlled Product

CAS: 10226-54-7

Applications Lomifylline is a methylxanthine analogue which induces Ca2+-release from intracellular stores via the ryanodine receptor.
References Sawynok, J., et al.: Drugs, 49, 37 (1995), Jacobson, K., et al.: J. Med. Chem., 35, 407 (1992), Wells, J., et al.: Methods Enzymol., 159, 489 (1988), Daly, J., et al.: J. Med. Chem., 29, 1305 (1986), Garst, J., et al.: J. Med. Chem., 19, 499 (1976),

Formula: C₁₃H₁₈N₄O₃

Color and Shape: Neat

Molecular weight: 278.31

Ref: TR-L470200

Lomifylline

Controlled Product

CAS: 10226-54-7

Lomifylline is a phosphodiesterase inhibitor that has been used in the treatment of inflammatory bowel disease, with some success. It works by inhibiting the enzyme phosphodiesterase, which breaks down cyclic AMP and cAMP. This leads to increased levels of cyclic AMP and cAMP, which promote cell proliferation. Lomifylline has been shown to be effective in treating bowel diseases such as Crohn's Disease, ulcerative colitis, and irritable bowel syndrome. Lomifylline is also used to reconstitute recombinant proteins that are insoluble. The drug does not work well for the treatment of Parkinson's disease or Alzheimer's disease because it does not enter the brain well enough to inhibit the enzyme production there.

Formula: C₁₃H₁₈N₄O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 278.31 g/mol

Ref: 3D-FL37566

Lomifylline

CAS: 10226-54-7

Lomifylline is an inducer that induces the release of Ca2+ stored in cells, specifically through the ryanodine receptor.

Formula: C₁₃H₁₈N₄O₃

Color and Shape: Solid

Molecular weight: 278.31

Ref: TM-T32855