CAS 102396-24-7

JASPLAKINOLIDE

Description:

Jasplakinolide is a cyclic peptide derived from the marine sponge *Jaspis johnstoni*. It is known for its ability to bind to actin filaments, thereby stabilizing them and preventing depolymerization, which makes it a valuable tool in cell biology for studying cytoskeletal dynamics. The compound exhibits a unique structure characterized by a cyclic arrangement of amino acids, contributing to its biological activity. Jasplakinolide has been shown to influence various cellular processes, including cell motility, shape, and division, by modulating the actin cytoskeleton. Additionally, it has potential applications in cancer research due to its effects on cell proliferation and apoptosis. The substance is typically used in laboratory settings, and its effects can vary depending on concentration and cell type. As with many bioactive compounds, careful consideration of its pharmacological properties and potential cytotoxicity is essential when designing experiments. Overall, jasplakinolide serves as an important tool for researchers investigating the complexities of cellular architecture and function.

Formula: C₃₆H₄₅BrN₄O₆

InChI: InChI=1/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1

Synonyms:

• Jasplakinolide, Jaspis Johnstoni
• (15E)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
• (4R,7R,10S,13R,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
• (4R,7R,10S,13S,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone

Jasplakinolide

CAS: 102396-24-7

Formula: C₃₆H₄₅BrN₄O₆

Color and Shape: Solid

Molecular weight: 709.6697

Ref: IN-DA0007CC

Jasplakinolide

CAS: 102396-24-7

Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits

Formula: C₃₆H₄₅BrN₄O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 709.67

Ref: TM-T11712

Jasplakinolide

CAS: 102396-24-7

Formula: C₃₆H₄₅BrN₄O₆

Purity: ≥ 97.0%

Color and Shape: Off-white to faint beige solid or film

Molecular weight: 709.7

Ref: 7W-GL4314

Jasplakinolide

Controlled Product

CAS: 102396-24-7

Formula: C₃₆H₄₅BrN₄O₆

Color and Shape: White To Light Yellow

Molecular weight: 709.67

Ref: TR-J210700

Jasplakinolide

CAS: 102396-24-7

Jasplakinolide is a cyclodepsipeptide, which is isolated from marine sponge species, particularly of the genus Jaspis. It functions by binding to actin, a critical component of cellular cytoskeletons, where it induces polymerization and stabilization of actin filaments. This action results in the disruption of normal actin dynamics, impeding processes such as cell motility and division.

Formula: C₃₆H₄₅BrN₄O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 709.67 g/mol

Ref: 3D-CEA39624