CAS 102417-94-7

4-(5-dimethylaminonaphth.-1-sulf.amino) phe. isothiocyanate

Description:

4-(5-Dimethylaminonaphth-1-sulfamoyl)phenyl isothiocyanate, with the CAS number 102417-94-7, is a chemical compound that belongs to the class of isothiocyanates, which are known for their diverse biological activities. This compound features a naphthalene ring substituted with a dimethylamino group and a sulfamoyl moiety, contributing to its unique properties. Isothiocyanates are often characterized by their pungent odor and are commonly found in cruciferous vegetables. They are known for their potential anticancer properties and ability to modulate various biological pathways. The presence of the dimethylamino group may enhance its solubility and reactivity, while the isothiocyanate functional group is known for its electrophilic nature, allowing it to react with nucleophiles in biological systems. This compound may be utilized in research settings, particularly in studies related to cancer biology and pharmacology, due to its potential to influence cellular mechanisms. However, specific safety and handling guidelines should be followed, as isothiocyanates can be toxic in certain concentrations.

Formula: C₁₉H₁₇N₃O₂S₂

InChI: InChI=1/C19H17N3O2S2/c1-22(2)18-7-3-6-17-16(18)5-4-8-19(17)26(23,24)21-15-11-9-14(10-12-15)20-13-25/h3-12,21H,1-2H3

SMILES: CN(C)c1cccc2c1cccc2S(=O)(=O)Nc1ccc(cc1)N=C=S

Synonyms:

• Dansylamino-PITC
• 4-[5-(Dimethylamino)-1-naphthalenesulfonylamino]phenyl isothiocyanate
• 5-(dimethylamino)-N-(4-isothiocyanatophenyl)naphthalene-1-sulfonamide

1-Naphthalenesulfonamide, 5-(dimethylamino)-N-(4-isothiocyanatophenyl)-

CAS: 102417-94-7

Formula: C₁₉H₁₇N₃O₂S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 383.4872

Ref: IN-DA0007EB

Dansylamino-PITC [Fluorescent Coupling Reagent for Edman Degradation]

CAS: 102417-94-7

Formula: C₁₉H₁₇N₃O₂S₂

Purity: >98.0%(HPLC)(N)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 383.48

Ref: 3B-A5354

4-(N-1-Dimethylaminonaphthalene-5-sulfonylamino)phenyl Isothiocyanate

Controlled Product

CAS: 102417-94-7

Stability Light Sensitive; Store at -20°C and Desicate.
Applications A fluorescent PITC homologue Edman-type reagent with similar coupling efficiency and repetitive degradation yield to those of PITC. Naphthalene derivatives may be particularly useful for preparing fluorescent drug or ligand analogues that are expected to bind to hydrophobic sites in proteins or membranes. The lipophilicity of these reagents may also facilitate the labelling of sites within the membrane-spanning portions of cellular proteins.Fluorescence: max. Abs. l = 335nm, max. Em. l = 536nm (in methanol)
References Gordon, E., et al.: Chem. Biol., 7, 9 (2000), Nagahori, N., et al.: ChemBioChem, 3, 836 (2002), Mrksich, M., et al.: Chem. Biol., 11, 739 (2004),

Formula: C₁₉H₁₇N₃O₂S₂

Color and Shape: Neat

Molecular weight: 383.49

Ref: TR-D461000